Evidence map›Paper›PMID 35755409›Full record

ArticleJournal of the Electrochemical Society2022

Electrochemical Determination of Manganese in Whole Blood with Indium Tin Oxide Electrode.

Zhizhen Wu, William R Heineman, Erin N Haynes, Ian Papautsky

Open access · greenAbstract read
In one paragraph

Article in Journal of the Electrochemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Automatic Microtitrator for Small Volume Samples.ACS measurement science au · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Zhizhen WuDepartment of Biomedical Engineering, University of Illinois Chicago, Illinois 60607, USA.
William R HeinemanDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, USA.
Erin N HaynesDepartment of Epidemiology and Preventive Medicine and Environmental Health, University of Kentucky, Kentucky 40536, USA.
Ian PapautskyDepartment of Biomedical Engineering, University of Illinois Chicago, Illinois 60607, USA.
University of Illinois Chicago · USUniversity of Cincinnati · USUniversity of Kentucky · US

Funding

Pilot Project ProgramP30ES026529 · NIEHS · UNIVERSITY OF KENTUCKY · PI Jason Unrine · 2017 to 2026
$15.4M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Developmental Effects of Manganese Exposure in Rural Adolescents: The CARES Cohort Comes of AgeR01ES026446 · NIEHS · UNIVERSITY OF KENTUCKY · PI CECIL, KIM M, HAYNES, ERIN N · 2016 to 2020
$3.1M
Retention, Maintenance and Enhancement of the Communities Actively Researching Exposure Study (CARES)R24ES030904 · NIEHS · UNIVERSITY OF KENTUCKY · PI HAYNES, ERIN N · 2020 to 2024
$1.8M
Validation and Demonstration of Point-of-Care Sensor for Multi-Metal Exposure AssessmentR33ES024717 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PAPAUTSKY, IAN · 2018 to 2020
$1.8M
Development of a lab-on-a-chip for point-of-care biomonitoring of blood metalsR01ES022933 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PAPAUTSKY, IAN · 2013 to 2016
$1.3M
NIEHS NIH HHS P30 ES026529NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R01 ES022933NIEHS NIH HHS R01 ES026446NIEHS NIH HHS R24 ES030904NIEHS NIH HHS R33 ES024717
6 · The paper itself

Abstract

In this work, we demonstrate accurate and precise measurement of manganese (Mn) concentration in human whole blood with indium tin oxide (ITO) electrode using square wave stripping voltammetry. While an essential trace metal for human health, elevated levels of Mn due to environmental or occupational exposure have been associated with severe neuromotor dysfunction characterized by parkinsonism and cognitive dysfunction making the monitoring of Mn in whole blood necessary. Pediatric populations are particularly susceptible to Mn given their developing brain and potential long-term impacts on neurodevelopment. The current gold standard for whole blood Mn measurements is by ICP-MS, which is costly and time consuming. The electrochemical detection with ITO working electrode in this work showed a limit of detection of 0.5 μg l

Identifiers

PMID35755409
PMCPMC9229665
OpenAlexW4224443220

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.