Evidence map›Paper›PMID 35755292›Full record

ArticleActa pharmaceutica Sinica. B2022

Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma.

Ying Liu, Yu Han, Shizhu Chen, Jingjie Liu, Dajiang Wang, Yifei Huang

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Photodynamic therapy with ring-fused chlorins: a vision-preserving approach for retinoblastoma.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  3. Effects of OACS applied bio materials · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Light-responsive biomaterials for ocular drug delivery.Drug delivery and translational research · 2023
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ying LiuDepartment of Ophthalmology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100144, China.
Yu HanCollege of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, China.
Shizhu ChenChina Resources Pharmaceutical Group Limited, Beijing 100000, China.
Jingjie LiuDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.
Dajiang WangDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.
Yifei HuangDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.
Chinese PLA General Hospital · CNCapital Medical University · CNChina Resources (China) · CNHebei University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photothermal therapy has the characteristics of minimal invasiveness, controllability, high efficiency, and strong specificity, which can effectively make up for the toxic side effects and tumor resistance caused by traditional drug treatment. However, due to the limited tissue penetration of infrared light, it is difficult to promote and apply in clinical practice. The eye is the only transparent tissue in human, and infrared light can easily penetrate the eye tissue, so it is expected that photothermal therapy can be used to treat fundus diseases. Here in, a new nano-platform assembled by liposome and indocyanine green (ICG) was used to treat retinoblastoma. ICG was assembled in liposomes to overcome some problems of ICG itself. For example, ICG is easily quenched, self-aggregating and instability. Moreover, liposomes can prevent free ICG from being cleared through the systemic circulation. The construction of the nano-platform not only ensured the stability of ICG

Indexed as

ARVO, Association for Research in Vision and OphthalmologyDLS, dynamic light scatteringDPPC, 1,2-dipalmitoyl-sn-glycero-3-phosphocholineDSPE-PEG2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[(polyethylene glycol)-2000]EE, encapsulation efficiencyFL, fluorescenceH&E, hematoxylin‒eosinICG, indocyanine greenILP, ICG-loaded liposomesImaging-guidedLiposomesLP, LiposomesNanoplatformPA, photoacousticPBS, phosphate-buffered salinePDT, photodynamic therapyPDTX, patient-derived tumor xenograftPhotothermal therapyPTT, photothermal therapyRb, retinoblastomaRetinoblastomaTEM, transmission electron microscopy

Identifiers

PMID35755292
PMCPMC9214327
OpenAlexW3209635863

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.