Evidence map›Paper›PMID 35755193›Full record

ArticleRSC chemical biology2022

A library of Rhodamine6G-based pH-sensitive fluorescent probes with versatile

W Benton Swanson, Margaret Durdan, Miranda Eberle, Seth Woodbury, Ava Mauser, Jason Gregory, Boya Zhang, David Niemann, Jacob Herremans, Peter X Ma and 4 more

Abstract read
In one paragraph

Article in RSC chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Collective Dynamics of Urease-Based Nanomotors in a Chemical Gradient.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  5. Article
  6. Review
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  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

W Benton SwansonDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan 1011 North University Avenue Ann Arbor MI 48109 USA wbentons@umich.edu.ORCID https://orcid.org/0000-0002-8074-7117
Margaret DurdanBiointerfaces Institute, College of Engineering and Medical School, University of Michigan Ann Arbor MI USA.
Miranda EberleDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan 1011 North University Avenue Ann Arbor MI 48109 USA wbentons@umich.edu.
Seth WoodburyDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan 1011 North University Avenue Ann Arbor MI 48109 USA wbentons@umich.edu.ORCID https://orcid.org/0000-0003-0510-8240
Ava MauserBiointerfaces Institute, College of Engineering and Medical School, University of Michigan Ann Arbor MI USA.
Jason GregoryBiointerfaces Institute, College of Engineering and Medical School, University of Michigan Ann Arbor MI USA.
Boya ZhangBiointerfaces Institute, College of Engineering and Medical School, University of Michigan Ann Arbor MI USA.
David NiemannDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan 1011 North University Avenue Ann Arbor MI 48109 USA wbentons@umich.edu.
Jacob HerremansDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan 1011 North University Avenue Ann Arbor MI 48109 USA wbentons@umich.edu.
Peter X MaDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan 1011 North University Avenue Ann Arbor MI 48109 USA wbentons@umich.edu.
Joerg LahannBiointerfaces Institute, College of Engineering and Medical School, University of Michigan Ann Arbor MI USA.
Megan WeivodaBiointerfaces Institute, College of Engineering and Medical School, University of Michigan Ann Arbor MI USA.
Yuji MishinaDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan 1011 North University Avenue Ann Arbor MI 48109 USA wbentons@umich.edu.
Colin F GreinederBiointerfaces Institute, College of Engineering and Medical School, University of Michigan Ann Arbor MI USA.

Funding

CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
Systemic Delivery of Targeted Bi-Compartmental Nanoparticles for Glioblastoma Therapeutics (Supplement)R01NS124167 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, JOERG LAHANN · 2022 to 2026
$2.6M
Regenerating cranial suture (Jaylynn Jones)R01DE027662 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HATCH, NAN E, MISHINA, YUJI · 2018 to 2022
$2.6M
A new model for spatio-temporal coupling of bone formation and bone resorption governed by osteoclastsR61AR078073 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISHINA, YUJI, PARK, DONGSU · 2020 to 2021
$694k
ICAM-1 targeted thrombomodulin: an experimental therapeutic for the Acute Respiratory Distress SyndromeK08HL130430 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GREINEDER, COLIN FRED · 2016 to 2020
$665k
A new model for spatio-temporal coupling of bone formation and bone resorption governed by osteoclastsR33AR078073 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISHINA, YUJI, PARK, DONGSU · 2023 to 2023
$393k
NHLBI NIH HHS K08 HL130430NIAMS NIH HHS R33 AR078073NIAMS NIH HHS R61 AR078073NIDCR NIH HHS R01 DE027662NIGMS NIH HHS T32 GM007315NINDS NIH HHS R01 NS124167
6 · The paper itself

Abstract

Acidic pH is critical to the function of the gastrointestinal system, bone-resorbing osteoclasts, and the endolysosomal compartment of nearly every cell in the body. Non-invasive, real-time fluorescence imaging of acidic microenvironments represents a powerful tool for understanding normal cellular biology, defining mechanisms of disease, and monitoring for therapeutic response. While commercially available pH-sensitive fluorescent probes exist, several limitations hinder their widespread use and potential for biologic application. To address this need, we developed a novel library of pH-sensitive probes based on the highly photostable and water-soluble fluorescent molecule, Rhodamine 6G. We demonstrate versatility in terms of both pH sensitivity (

Identifiers

PMID35755193
PMCPMC9175114

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.