Evidence map›Paper›PMID 35755058›Full record

ArticleFrontiers in medicine2022

False-Positive Results of SARS-CoV-2 RT-PCR in Oropharyngeal Swabs From Vaccinators.

Xiang-Qi Kong, Yong-Jing Wang, Zan-Xi Fang, Tian-Ci Yang, Man-Li Tong

Abstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Hybridization-driven fluorometric platform based on metal-organic frameworks for the identification of the highly homologous viruses.Microchemical journal : devoted to the application of microtechniques in all branches of science · 2023
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiang-Qi KongCenter of Clinical Laboratory, School of Medicine, Zhongshan Hospital, Xiamen University, Xiamen, China.
Yong-Jing WangCenter of Clinical Laboratory, School of Medicine, Zhongshan Hospital, Xiamen University, Xiamen, China.
Zan-Xi FangCenter of Clinical Laboratory, School of Medicine, Zhongshan Hospital, Xiamen University, Xiamen, China.
Tian-Ci YangCenter of Clinical Laboratory, School of Medicine, Zhongshan Hospital, Xiamen University, Xiamen, China.
Man-Li TongCenter of Clinical Laboratory, School of Medicine, Zhongshan Hospital, Xiamen University, Xiamen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Real-time reverse transcription-polymerase chain reaction (RT-PCR) is the gold standard for diagnosing coronavirus disease 2019 (COVID-19). However, RT-PCR may yield false-positive results, leading to unnecessary countermeasures. Here, we report a "positive" nucleic acid test on a 10-pooled sample during the routine screening that caused many adverse societal effects, and financial and resource losses. However, they were subsequently determined to be a case of vaccine contamination. This case study increases awareness of false-positive RT-PCR results for SARS-CoV-2, especially when participants are vaccinators. Moreover, it could provide relevant suggestions to prevent the recurrence of such incidents.

Indexed as

contaminationfalse positiveRT-PCRSARS-CoV-2vaccine

Identifiers

PMID35755058
PMCPMC9226675

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.