Evidence map›Paper›PMID 35755057›Full record

ArticleFrontiers in medicine2022

Red Blood Cell Distribution Width Is Associated With Adverse Kidney Outcomes in Patients With Chronic Kidney Disease.

Xinwei Deng, Bixia Gao, Fang Wang, Ming-Hui Zhao, Jinwei Wang, Luxia Zhang

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03041987 (Chinese Cohort Study of Chronic Kidney Disease), which is not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03041987 active not recruitingnot on this map

Chinese Cohort Study of Chronic Kidney Disease

TypeobservationalSponsorPeking University First HospitalRan2012 to 2026Enrolled5,000ConditionsRenal Insufficiency, ChronicArmsDemographic factors, biomedical measurements, drugs used for controlling metabolic disorders, etc
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Xinwei DengRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Bixia GaoRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Fang WangRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Ming-Hui ZhaoRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Jinwei WangRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Luxia ZhangRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNCenter for Life Sciences · CNPeking University · CNPeking University First Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic kidney disease (CKD) is a global public health issue. Red blood cell distribution width (RDW) is a recently recognized potential inflammatory marker, which mirrors the variability in erythrocyte volume. Studies indicate that elevated RDW is associated with increased risk of mortality in CKD patients, while evidence regarding the impact of RDW on kidney outcome is limited. Methods: Altogether 523 patients with CKD stage 1-4 from a single center were enrolled. We identified the cutoff point for RDW level using maximally selected log-rank statistics. The time-averaged estimated glomerular filtration rate (eGFR) slope was determined using linear mixed effects models. Rapid CKD progression was defined by an eGFR decline >5 ml/min/1.73 m Results: During a median follow-up of 26 [interquartile range (IQR): 12, 36] months, 65 (12.43%) patients suffered a rapid CKD progression and 172 (32.89%) composite kidney events occurred at a rate of 32.3/100 patient-years in the high RDW group, compared with 14.7/100 patient-years of the remainder. The annual eGFR change was clearly steeper in high RDW group {-3.48 [95% confidence interval (CI): -4.84, -2.12] ml/min/1.73 m Conclusion: Increased RDW value is independently associated with accelerated CKD deterioration. Findings of this study suggest RDW be a potential indicator for risk of CKD progression.

Indexed as

chronic kidney disease (CKD)estimated glomerular filtration rate (eGFR) slopekidney outcomesrapid CKD progressionred blood cell distribution width

Identifiers

PMID35755057
PMCPMC9218182
OpenAlexW4281674488

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.