ArticleFrontiers in human neuroscience2022
Different Roles of the Left and Right Ventrolateral Prefrontal Cortex in Cognitive Reappraisal: An Online Transcranial Magnetic Stimulation Study.
Article in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 24 citations in OpenAlex.
- Characterization of neural networks involved in transdiagnostic emotion dysregulation from a pilot randomized controlled trial of a neurostimulation-enhanced behavioral intervention.Psychiatry research. Neuroimaging · 2024Trial
- A randomized trial that compared brain activity, efficacy and plausibility of open-label placebo treatment and cognitive repappraisal for reducing emotional distress.Scientific reports · 2023Trial
- Affect labeling down-regulates amygdala only in a dominant native language.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neural Markers of Reward Valuation and Impulsive Decision-Making in Mania Risk.JAMA psychiatry · 2026Article
- Cognitive reappraisal modulates neural responses to aversive sensory stimulation in autistic youth.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Testosterone, cortisol, and fNIRS-based cortical activation associated with competitive task persistence and difficulty.Journal of neuroendocrinology · 2026Article
- Neural correlates of map representation and spatial orientation in orienteering experts: an fNIRS study.Frontiers in human neuroscience · 2026Article
- Fronto-cingulate gamma synchrony predicts deep brain stimulation response in treatment-resistant depression: preliminary evidence.Journal of psychiatry & neuroscience : JPN · 2026Article
- Neurophysiological Markers of Regulation Success in Everyday Life in Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Dissociating the Role of Dorsolateral Prefrontal Cortex and Ventrolateral Prefrontal Cortex in Cognitive Control in Depression: A Combined HD-tDCS and fNIRS Study.Brain topography · 2025Article
- Subcortical modulation of the salience network during negative emotional processing in mood and anxiety disorders.Molecular psychiatry · 2025Article
- Brain Activation in Response to Literature-Related Activities.Psychiatry investigation · 2025Article
- Abnormal Gyrus Rectus Asymmetry in Alzheimer's Disease: An MRI-Based Parcellation Method.Brain sciences · 2025Article
- Article
- Gender Differences in Prefrontal Cortex Response to Negative Emotional Stimuli in Drivers.Brain sciences · 2024Article
- Functional magnetic resonance imaging study of group independent components underpinning item responses to paranoid-depressive scale.World journal of clinical cases · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ventrolateral prefrontal cortex (VLPFC) plays a pivotal role in cognitive reappraisal. Previous studies suggested a functional asymmetry of the bilateral VLPFC, but the evidence is still insufficient during cognitive reappraisal. In this study, we conducted an online single-pulse transcranial magnetic stimulation (spTMS) to investigate the causal and distinct roles of the left and right VLPFC in reappraisal. Participants were instructed to reappraise (down-regulate) or attend to pictures depicting social exclusion scenarios while the spTMS was applied over the left or right VLPFC of the participants' brains. The results showed that spTMS of either the left or the right VLPFC would increase reappraisal difficulty. Meanwhile, the outcome of reappraisal (measured by self-reported negative feelings) significantly deteriorated when the right (but not the left) VLPFC was temporally interrupted by spTMS, while the verbal fluency during oral reporting of the reappraisal strategy was significantly reduced when the left VLPFC was interrupted by spTMS. Taken together, these findings provide causal evidence for the involvement of left and right VLPFC with distinct roles: while the left VLPFC is responsible for the linguistic especially semantic process of generating and selecting appraisals according to the goal of emotion regulation, the right VLPFC plays a critical role in inhibiting inappropriate negative emotions and thoughts generated by the effective scenarios. These findings deepen our understanding of the neurocognitive mechanism of emotion regulation.
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