ArticleiScience2022
Melanopsin photoreception differentially modulates rod-mediated and cone-mediated human temporal vision.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Increased brightness assimilation in rod vision.iScience · 2025Article
- Within-subjects ultra-short sleep-wake protocol for characterising circadian variations in retinal function.PloS one · 2025Article
- Intrinsically photosensitive retinal ganglion cells and visual processing: ipRGCs beyond non-image-forming functions.Frontiers in neuroscience · 2025Review
- What can the eye see with melanopsin?Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Illumination by short-wavelength light inside the blind spot decreases light detectability.iScience · 2024Article
- Melanopsin-mediated amplification of cone signals in the human visual cortex.Proceedings. Biological sciences · 2024Article
- Targeting sleep and the circadian system as a novel treatment strategy for Parkinson's disease.Journal of neurology · 2024Article
- Melanopsin enhances image persistence.Current biology : CB · 2023Article
- PySilSub: An open-source Python toolbox for implementing the method of silent substitution in vision and nonvisual photoreception research.Journal of vision · 2023Article
- A five-primary Maxwellian-view display for independent control of melanopsin, rhodopsin, and three-cone opsins on a fine spatial scale.Journal of vision · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the nature of interactions between visual pathways transmitting the slower melanopsin and faster rod and cone signals, we implement a temporal phase summation paradigm in human observers using photoreceptor-directed stimuli. We show that melanopsin stimulation interacts with and alters both rod-mediated and cone-mediated vision regardless of whether it is perceptually visible or not. Melanopsin-rod interactions result in either inhibitory or facilitatory summation depending on the temporal frequency and photoreceptor pathway contrast sensitivity. Moreover, by isolating rod vision, we reveal a bipartite intensity response property of the rod pathway in photopic lighting that extends its operational range at lower frequencies to beyond its classic saturation limits but at the expense of attenuating sensitivity at higher frequencies. In comparison, melanopsin-cone interactions always lead to facilitation. These interactions can be described by linear or probability summations and potentially involve multiple intraretinal and visual cortical pathways to set human visual contrast sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.