Evidence map›Paper›PMID 35754571›Full record

ArticleProceedings (Baylor University. Medical Center)2022

Van Wyk-Grumbach syndrome and trisomy 21.

Aleida Rivera-Hernández, Mónica Margarita Madrigal-González, Rossana Espinosa-Peniche, Jessie Zurita-Cruz, Lourdes Balcázar-Hernández

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings (Baylor University. Medical Center), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Van Wyk-Grumbach Syndrome and Gonadectomy.Children (Basel, Switzerland) · 2024
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Aleida Rivera-HernándezPediatric Endocrinology Department, Hospital de Pediatría, UMAE CMN Siglo XXI, IMSS, Mexico City, Mexico.ORCID https://orcid.org/0000-0002-4363-691X
Mónica Margarita Madrigal-GonzálezPediatric Endocrinology Department, Hospital de Pediatría, UMAE CMN Siglo XXI, IMSS, Mexico City, Mexico.ORCID https://orcid.org/0000-0001-8354-8925
Rossana Espinosa-PenichePediatric Department, UMAE IMSS Mérida, Mérida, Yucatán, Mexico.ORCID https://orcid.org/0000-0002-0324-6976
Jessie Zurita-CruzNutrition Research Unit, Hospital de Pediatría, UMAE CMN Siglo XXI, IMSS, Mexico City, Mexico.ORCID https://orcid.org/0000-0003-1389-7964
Lourdes Balcázar-HernándezEndocrinology Department, Hospital de Especialidades, UMAE CMN Siglo XXI, IMSS, Mexico City, Mexico.ORCID https://orcid.org/0000-0002-0373-6641
Mexican Social Security Institute · MXHospital de Especialidades · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Van Wyk-Grumbach syndrome (VWGS) is characterized by severe hypothyroidism, peripheral precocious puberty, delayed bone age, hyperestrogenism, prepubertal luteinizing hormone, and elevated follicle-stimulating hormone. Patients with Down syndrome have a high susceptibility and prevalence of thyroid disorders. However, the coexistence of VWGS and trisomy 21 is uncommon. We present a case of a 5-year-old Mexican girl with Down syndrome, severe autoimmune hypothyroidism, pituitary enlargement, hyperprolactinemia, peripheral precocious puberty, multiple ovarian cysts, and delayed bone age, with a clinical diagnosis of VWGS. The patient presented with a remission of these manifestations after treatment with levothyroxine. Patients with Down syndrome, precocious puberty, hyperestrogenism, prepuberal luteinizing hormone, high follicle-stimulating hormone, and delayed bone age should be evaluated with a thyroid profile due to the possibility of VWGS.

Indexed as

Down syndromehypothyroidismpituitary hyperplasiaVan Wyk-Grumbach syndrome

Identifiers

PMID35754571
PMCPMC9196775
OpenAlexW4220868668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.