Evidence map›Paper›PMID 35754546›Full record

ArticleFrontiers in veterinary science2022

Weighted Gene Co-expression Network Analysis Identifies Specific Modules and Hub Genes Related to Subacute Ruminal Acidosis.

Qiuju Wang, Bingnan Gao, Xueqing Yue, Yizhe Cui, Juan J Loor, Xiaoxia Dai, Xu Wei, Chuang Xu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Qiuju WangCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, China.
Bingnan GaoCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, China.
Xueqing YueCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, China.
Yizhe CuiCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, China.
Juan J LoorDepartment of Animal Sciences, Division of Nutritional Sciences, University of Illinois, Urbana, IL, United States.
Xiaoxia DaiThe Royal Veterinary College, University of London, London, United Kingdom.
Xu WeiDepartment of Biosystems, Division of Animal and Human Health Engineering, KU Leuven, Leuven, Belgium.
Chuang XuCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, China.
Heilongjiang Bayi Agricultural University · CNKU Leuven · BERoyal Veterinary College · GBUniversity of Illinois Urbana-Champaign · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Weighted gene co-expression network analysis (WGCNA) was used to understand the pathogenesis of subacute ruminal acidosis (SARA) and identify potential genes related to the disease. Microarray data from dataset GSE143765, which included 22 cows with and nine cows without SARA, were downloaded from the NCBI Gene Expression Omnibus (GEO). Results of WGCNA identified highly correlated modules of sample genes, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses allowed further biological insights into SARA-related modules. The protein-protein interaction (PPI) network, modules from the PPI network, and cistron annotation enrichment of modules were also analyzed. A total of 14,590 DEGs were used for the WGCNA. Construction of a protein-protein network identified

Indexed as

bioinformatic analysisdifferentially expressed genesinflammatory responsesubacute ruminal acidosistransmembrane signaling

Identifiers

PMID35754546
PMCPMC9226770
OpenAlexW4281800783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.