ArticleComprehensive psychoneuroendocrinology2021
Allostatic load scoring using item response theory.
Article in Comprehensive psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Allostatic Load in Children and Adolescents: A Systematic Review.Psychotherapy and psychosomatics · 2023Pooled it
- Allostatic Load Measurement: A Systematic Review of Reviews, Database Inventory, and Considerations for Neighborhood Research.International journal of environmental research and public health · 2022Pooled it
- Prenatal allostatic load and preterm birth: A systematic review.Frontiers in psychology · 2022Pooled it
- Mid-Trimester Allostatic Load and Spontaneous Preterm Birth in a Cohort of Pregnant Women Living with HIV in Zambia.Maternal and child health journal · 2025Trial
- The Effect of a Video-Assisted Health Education Program Followed by Peer Education on the Health Literacy of COVID-19 and Other Infectious Diseases Among School Children: Quasi-Randomized Controlled Trial.JMIR human factors · 2024Trial
- Associations between volatile organic compound mixtures and allostatic load: Evidence from the Green Heart Louisville Project.Environmental research · 2026Article
- Comorbid Conditions of Ehlers-Danlos Syndromes and Vulvodynia: A Latent Class Analysis.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2026Article
- Review
- Allostatic Load, Multimorbidity, and Overall and Cancer-Specific Survival among Older Adults in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Association Between Allostatic Load and Incident Colorectal Cancer-A Prospective Study in a Multiethnic Asian Population.Cancer medicine · 2026Article
- L-SOLCO Pilot Study: Examining Allostatic Load and Cancer Treatment Disparities.Journal of racial and ethnic health disparities · 2026Article
- Quantifying PFAS-Omics Burden Scores for Nontargeted Analysis Using Multidimensional Item Response Theory: An Exploratory Analysis of Novel and Legacy PFAS in Cord Blood.Environmental science & technology · 2026Article
- Allostatic (over) load measurement: Workflow and repository.PloS one · 2026Article
- Maternal allostatic load in pregnancy is prospectively associated with child adiposity and metabolic function across infancy and early childhood.Psychoneuroendocrinology · 2025Article
- Intersecting race/ethnicity and gender in physiological dysregulation profiles and associations with socioeconomic status among older adults in the United States.SSM - population health · 2025Article
- Vascular-related biological stress, DNA methylation, allostatic load and domain-specific cognition: an integrated machine learning and causal inference approach.BMC neurology · 2025Article
- Racial Disparities in COVID-19 Severity Are Partially Mediated by Chronic Stress-Evidence from a Large Integrated Healthcare System.Journal of racial and ethnic health disparities · 2025Observational
- Exposome Burden Scores to Summarize Environmental Chemical Mixtures: Creating a Fair and Common Scale for Cross-study Harmonization, Report-back and Precision Environmental Health.Current environmental health reports · 2025Review
- "Rest of the folks are tired and weary": The impact of historical lynchings on biological and cognitive health for older adults racialized as Black.Social science & medicine (1982) · 2025Article
- Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children.Environmental research · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Allostatic load is commonly operationalized using a sum-score of high-risk biomarkers. However, this method implies that biomarkers contribute equally to allostatic load, as each is given equal weight. Our goal in this methodological paper is to evaluate this, and complementarily, to identify biomarkers that are most informative and least informative for developing an allostatic load index. Item response theory models provide an alternate approach to calculating the allostatic load score, by treating individual biomarkers (e.g. "items") as indicators of a latent allostatic load construct. Item response theory scores account for the data-driven discriminating power of each biomarker, and an individual's pattern of biomarker responses. To demonstrate feasibility of this approach, we used data from the 2015-2016 National Health Examination and Nutrition Survey (NHANES;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.