Evidence map›Paper›PMID 35754341›Full record

ArticleThe Australian & New Zealand journal of obstetrics & gynaecology2022

Primary dysmenorrhoea in adolescents and young women: A twin family study of maternal transmission, genetic influence and associations.

Phillip Aouad, Minh Bui, Sara Sarraf, Theresa Donnelly, Yuxi Chen, Tiina Jaaniste, John Eden, G David Champion

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Australian & New Zealand journal of obstetrics & gynaecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Disease Burden of Dysmenorrhea: Impact on Life Course Potential.International journal of women's health · 2023
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Phillip AouadDepartment of Pain, Sydney Children's Hospital, Randwick, New South Wales, Australia.ORCID 0000-0003-0999-7495
Minh BuiSchool of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Sara SarrafDepartment of Pain, Sydney Children's Hospital, Randwick, New South Wales, Australia.
Theresa DonnellyDepartment of Pain, Sydney Children's Hospital, Randwick, New South Wales, Australia.
Yuxi ChenDepartment of Pain, Sydney Children's Hospital, Randwick, New South Wales, Australia.
Tiina JaanisteDepartment of Pain, Sydney Children's Hospital, Randwick, New South Wales, Australia.
John EdenSchool of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
G David ChampionDepartment of Pain, Sydney Children's Hospital, Randwick, New South Wales, Australia.
Sydney Children's Hospital · AUUNSW Sydney · AUThe University of Melbourne · AUThe University of Sydney · AU

Funding

University of New South Wales, Australia
6 · The paper itself

Abstract

aimsThe extent to which maternal transmission of primary dysmenorrhoea is genetically determined in adolescents and young women has yet to be determined. We aimed to assess heritability and associations relevant to primary pain syndromes using a twin family study.

methodsParticipants were young menstruating female twins, and their oldest sisters and mothers, whose families were registered with Twins Research Australia and previously participated in a twin family study of primary paediatric pain disorders. Questionnaire packs were mailed, assessing current maximum and average menstrual pain intensity, current pain interference with activities and retrospective dysmenorrhea secondary symptoms.

resultsThe sample comprised 206 twin individuals (57 monozygous (MZ) and 46 dizygous (DZ) pairs) aged 10-22 years, eldest siblings (n = 38) aged 13-28 years and mothers (n = 101) aged 32-61 years. The estimated regression coefficient of the relationship between mother-daughter and twin-sibling dyads indicated significant associations for the measures of dysmenorrhea and supported heritability. Adjusted for age, the within twin-pair correlation for MZ twins was generally more than twice that of DZ twins. Heritability estimates were maximal pain intensity 0.67 (P = 3.8 × 10

conclusionPrimary dysmenorrhea in adolescents and young women was shown to be relatively strongly genetically influenced and associated especially with a history of iron deficiency and painless RLS which have potential therapeutic implications.

Indexed as

DysmenorrheaTwins, DizygoticAdolescentChildFemaleHumansMothersRetrospective StudiesTwins, Monozygoticadolescentsassociationsdysmenorrhoeafamilygenetic

Identifiers

PMID35754341
PMCPMC9796909
OpenAlexW4283593816

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.