Evidence map›Paper›PMID 35754296›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Targeting Bone Tumor and Subcellular Endoplasmic Reticulum via Near Infrared II Fluorescent Polymer for Photodynamic-Immunotherapy to Break the Step-Reduction Delivery Dilemma.

Xianghong Zhang, Jia Wan, Fuhao Mo, Dongsheng Tang, Haihua Xiao, Zhihong Li, Jinpeng Jia, Tang Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Xianghong ZhangDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, P. R. China.
Jia WanDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, P. R. China.
Fuhao MoState Key Laboratory of Advanced Design and Manufacture for Vehicle Body, Hunan University, Changsha, Hunan, 410082, P. R. China.
Dongsheng TangBeijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Haihua XiaoBeijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Zhihong LiDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, P. R. China.
Jinpeng JiaSenior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Beijing, 100853, P. R. China.
Tang LiuDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, P. R. China.ORCID 0000-0002-0040-4270
Central South University · CNChinese Academy of Sciences · CNChinese PLA General Hospital · CNHunan University · CN

Funding

Fundamental Research Funds for Central Universities of the Central South University 2020zzts288National Natural Science Foundation of China 81672176National Natural Science Foundation of China 81871783National Natural Science Foundation of China 82072441Scientific Research Project of Hunan Health Committee 20200357
6 · The paper itself

Abstract

Specific localization of photosensitizers (PSs) to a certain organelle could result in targeted attack to cause greater trauma to cancer cells, eventually maximizing photodynamic therapy (PDT). However, currently, efficient and precise transportation of PSs via drug delivery to tumor cells and subcellular organelles is still challenging, due to a so-called step-reduction delivery dilemma (SRDD) which also threatens anticancer drug delivery to exert their efficacy. Herein, a cascade targeting near infrared II (NIR II) fluorescent nanoparticles (NP

Indexed as

Bone NeoplasmsPolymersDrug Delivery SystemsEndoplasmic ReticulumHumansImmunotherapyPhotosensitizing AgentsReactive Oxygen SpeciesPhotosensitizing AgentsPolymersReactive Oxygen Speciescascade targetingendoplasmic reticulum stressphotodynamic-immunotherapystep-reduction delivery dilemma

Identifiers

PMID35754296
PMCPMC9404413
OpenAlexW4283581824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.