Evidence map›Paper›PMID 35754287›Full record

ArticleJournal of Parkinson's disease2022

Establishing Equivalent Aerobic Exercise Parameters Between Early-Stage Parkinson's Disease and Pink1 Knockout Rats.

Michael F Salvatore, Isabel Soto, Ella A Kasanga, Rachael James, Marla K Shifflet, Kirby Doshier, Joel T Little, Joshia John, Helene M Alphonso, J Thomas Cunningham and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Neurobiology of exercise in Parkinson's disease.Journal of Parkinson's disease · 2026
    Review
  5. Review
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Michael F SalvatoreDepartment of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
Isabel SotoDepartment of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
Ella A KasangaDepartment of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
Rachael JamesDepartment of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
Marla K ShiffletDepartment of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
Kirby DoshierDepartment of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
Joel T LittleDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.
Joshia JohnTexas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA.
Helene M AlphonsoJohn Peter Smith Health Network, Fort Worth, TX, USA.
J Thomas CunninghamDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.
Vicki A NejtekDepartment of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
University of North Texas · USJohn Peter Smith Hospital · US

Funding

Training in the Neurobiology of Aging and Alzheimer's DiseaseT32AG020494 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ROBERT Clinton BARBER, NATHALIE SUMIEN · 2002 to 2026
$6.9M
Intermittent hypoxia and hypertension: Role of the lamina terminalisR01HL155977 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI FARMER, GEORGE EDWARD · 2021 to 2024
$2.7M
NHLBI NIH HHS R01 HL155977NIA NIH HHS T32 AG020494
6 · The paper itself

Abstract

backgroundRodent Parkinson's disease (PD) models are valuable to interrogate neurobiological mechanisms of exercise that mitigate motor impairment. Translating these mechanisms to human PD must account for physical capabilities of the patient.

objectiveTo establish cardiovascular parameters as a common metric for cross-species translation of aerobic exercise impact.

methodWe evaluated aerobic exercise impact on heart rate (HR) in 21 early-stage PD subjects (Hoehn Yahr ≤1.5) exercising in non-contact boxing training for ≥3 months, ≥3x/week. In 4-month-old Pink1 knockout (KO) rats exercising in a progressively-increased treadmill speed regimen, we determined a specific treadmill speed that increased HR to an extent similar in human subjects.

resultsAfter completing aerobic exercise for ∼30 min, PD subjects had increased HR∼35% above baseline (∼63% maximum HR). Motor and cognitive test results indicated the exercising subjects completed the timed up and go (TUG) and trail-making test (TMT-A) in significantly less time versus exercise-naïve PD subjects. In KO and age-matched wild-type (WT) rats, treadmill speeds of 8-10 m/min increased HR up to 25% above baseline (∼67% maximum HR), with no further increases up to 16 m/min. Exercised KO, but not WT, rats showed increased locomotor activity compared to an age-matched exercise-naïve cohort at 5 months old.

conclusionThese proof-of-concept results indicate HR is a cross-species translation parameter to evaluate aerobic exercise impact on specific motor or cognitive functions in human subjects and rat PD models. Moreover, a moderate intensity exercise regimen is within the physical abilities of early-stage PD patients and is therefore applicable for interrogating neurobiological mechanisms in rat PD models.

Indexed as

Parkinson DiseaseAnimalsExercise TestExercise TherapyHeart RateHumansInfantRatsagingcardiovascularExerciselocomotorParkinson’s diseasePink1

Identifiers

PMID35754287
PMCPMC9535586
OpenAlexW4283392263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.