ArticleInternational journal of laboratory hematology2022
Harmonizing platelet function analyzer testing and reporting in a large laboratory network.
Article in International journal of laboratory hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Serial Examination of Platelet Function Tests Might Predict Prognosis of Patients with Acute Ischemic Stroke-A Cohort Study.Diagnostics (Basel, Switzerland) · 2024Article
- Platelet RNA sequencing reveals profile of caffeic acid affecting hemostasis in mice.Research and practice in thrombosis and haemostasis · 2024Article
- Feasibility and comparability of different platelet function tests in acute stroke with or without prior antiplatelet therapy.Frontiers in neurology · 2024Article
- The effect of recombinant versus plasma-derived von Willebrand factor on prolonged PFA closure times in ECMO patients with acquired von Willebrand syndrome - an observational study.Thrombosis journal · 2023Article
- Auto-validation of Routine Coagulation/Hemostasis Assays with Reflex Testing of Abnormal Test Results.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Harmonizing platelet function analyzer testing and reporting in a large laboratory network.International journal of laboratory hematology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 1 country.
Funding
Abstract
introductionThe platelet function analyzer (PFA) is a popular platelet function screening instrument, highly sensitive to von Willebrand disease (VWD) and to aspirin therapy, with moderate sensitivity to defects in platelet function and/or deficiencies in platelet number. There are two models, the original PFA-100 and the contemporary PFA-200. Normal reference ranges (NRRs) provided by the manufacturer are the same for both models, instead being based on the type of test cartridge, for which there are two main ones: collagen/epinephrine (C/Epi) and collagen/adenosine diphosphate (C/ADP).
methodsComparative evaluations of PFA testing and reporting in six different sites of a large pathology network, aiming to harmonize NRRs and test reporting across all network sites. A separate comparative study of testing a range of samples (n > 150) on a PFA-100 versus that on a PFA-200. Review of contemporary literature.
resultsEach site was identified to have a different reporting NRR, which after consolidating data permitted establishment of an agreed harmonized NRR for use across the network (C/Epi: 90-160; C/ADP: 70-124; based on n > 180). Similarly, each site reported and interpreted results in different ways, and after discussion and consolidation, a harmonized approach to interpretation and reporting was achieved. The separate comparative study of PFA-100 versus PFA-200 testing confirmed instrument equivalence.
conclusionWe achieved harmonized NRRs and reporting for PFA testing across a large pathology network. Our approach may be useful for other laboratory networks wishing to harmonize PFA testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.