ArticleBiophysical journal2022
Systematic measurements of interleaflet friction in supported bilayers.
Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Electromechanically induced membrane restructuring enables learning and memory.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A unifying model of LAT condensates in reconstitution experiments.bioRxiv : the preprint server for biology · 2025Article
- Local mapping of the nanoscale viscoelastic properties of fluid membranes by AFM nanorheology.Nature communications · 2025Article
- Effects of a Polarizable Force Field on Membrane Dynamics: Surface Viscosity, Lipid Diffusion, and Peptide Induced Pore Formation.Journal of computational chemistry · 2025Article
- Curvature fluctuations of fluid vesicles reveal hydrodynamic dissipation within the bilayer.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Forces and Flows at Cell Surfaces.The Journal of membrane biology · 2023Review
- Discovery of Kinetic Trapping of Poloxamers inside Liposomes via Thermal Treatment.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Membrane free-energy landscapes derived from atomistic dynamics explain nonuniversal cholesterol-induced stiffening.PNAS nexus · 2023Article
- Passive and reversible area regulation of supported lipid bilayers in response to fluid flow.Biophysical journal · 2023Article
- Neutron scattering studies on dynamics of lipid membranes.Biophysics reviews · 2023Review
- Measuring flow-mediated protein drift across stationary supported lipid bilayers.Biophysical journal · 2023Article
- Surface viscosities of lipid bilayers determined from equilibrium molecular dynamics simulations.Biophysical journal · 2023Article
- Molecular mechanism of GTP binding- and dimerization-induced enhancement of Sar1-mediated membrane remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Membrane free-energy landscapes derived from atomistic dynamics explain nonuniversal cholesterol-induced stiffening.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
When lipid membranes curve or are subjected to strong shear forces, the two apposed leaflets of the bilayer slide past each other. The drag that one leaflet creates on the other is quantified by the coefficient of interleaflet friction, b. Existing measurements of this coefficient range over several orders of magnitude, so we used a recently developed microfluidic technique to measure it systematically in supported lipid membranes. Fluid shear stress was used to force the top leaflet of a supported membrane to slide over the stationary lower leaflet. Here, we show that this technique yields a reproducible measurement of the friction coefficient and is sensitive enough to detect differences in friction between membranes made from saturated and unsaturated lipids. Adding cholesterol to saturated and unsaturated membranes increased interleaflet friction significantly. We also discovered that fluid shear stress can reversibly induce gel phase in supported lipid bilayers that are close to the gel-transition temperature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.