SynthesisPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2022
Multi-ancestry genome-wide association study of asthma exacerbations.
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In one paragraph
Synthesis in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Multi-ancestry genome-wide association study of asthma exacerbations.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Pooled it
- Genome-wide association study of asthma with high treatment burden and/or worse outcomes defined using electronic healthcare data in UK Biobank.ERJ open research · 2026Article
- Airway macrophage specific glycocalyx expression and remodeling following viral infection.Matrix biology : journal of the International Society for Matrix Biology · 2026Article
- αThe journal of allergy and clinical immunology. In practice · 2025Article
- Gut microbiota constituents may affect hypertrophic scarring risk through interaction with specific immune cells in a two-step, two-sample Mendelian randomization study.Scientific reports · 2025Article
- Pharmacogenetics of childhood uncontrolled asthma.Expert review of clinical immunology · 2025Review
- Peripheral blood miRNAs are associated with airflow below threshold in children with asthma.Respiratory research · 2025Article
- Genetics of chronic respiratory disease.Nature reviews. Genetics · 2024Review
- Asthma exacerbations and eosinophilia in the UK Biobank: a genome-wide association study.ERJ open research · 2024Article
- 5-HTP inhibits eosinophilia via intracellular endothelial 5-HTRs; SNPs in 5-HTRs associate with asthmatic lung function.Frontiers in allergy · 2024Article
- Multi-omics in exploring the pathophysiology of diabetic retinopathy.Frontiers in cell and developmental biology · 2024Review
- Prediction of asthma using a four-locus gene model including IL13, IL4, FCER1B, and ADRB2 in children of Kazak nationality.Italian journal of pediatrics · 2023Article
- Asthma Exacerbations: The Genes Behind the Scenes.Journal of investigational allergology & clinical immunology · 2023Review
- Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme.Clinical and translational allergy · 2023Review
- Leveraging genetic ancestry to study severe asthma exacerbations in an admixed population.Thorax · 2023Article
- Immunogenetics and pharmacogenetics of allergic asthma in Africa.Frontiers in allergy · 2023Review
Corrections and comments
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Authors and funding
64 authors at 20 institutions in 12 countries.
Esther Herrera-LuisGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), San Cristóbal de La Laguna, Tenerife, Spain.ORCID 0000-0003-4150-5454
Victor E OrtegaDivision of Respiratory Medicine, Department of Internal Medicine, Mayo Clinic, Scottsdale, Arizona, USA.
Elizabeth J AmplefordDepartment of Internal Medicine, Center for Precision Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Yang Yie SioDepartment of Biological Sciences, National University of Singapore, Singapore City, Singapore.
Raquel GranellMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-4890-4012
Emmely de RoosDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Natalie TerzikhanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Ernesto Elorduy VergaraInstitute of Computation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
Natalia Hernandez-PachecoDepartment of Clinical Sciences and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-6313-1847
Javier Perez-GarciaGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), San Cristóbal de La Laguna, Tenerife, Spain.ORCID 0000-0001-7813-4381
Elena Martin-GonzalezGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), San Cristóbal de La Laguna, Tenerife, Spain.
Fabian Lorenzo-DiazGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), San Cristóbal de La Laguna, Tenerife, Spain.ORCID 0000-0002-3398-198X
Simone HashimotoDepartment of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-8995-3817
Paul BrinkmanDepartment of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
U-BIOPRED Study Group
Andrea L JorgensenDepartment of Health Data Science, Institute of Population Health, University of Liverpool, Liverpool, UK.
Qi YanDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-5236-9673
Erick FornoDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-6497-9885
Susanne J VijverbergDepartment of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-4579-4081
Ryan LethemMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Antonio Espuela-OrtizGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), San Cristóbal de La Laguna, Tenerife, Spain.ORCID 0000-0003-0572-9549
Mario GorenjakCenter for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.ORCID 0000-0003-4208-9683
Celeste EngDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Ruperto González-PérezAllergy Department, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Tenerife, Spain.
José M Hernández-PérezPulmonary Medicine, Hospital Universitario de N.S de Candelaria, Santa Cruz de Tenerife, Spain.ORCID 0000-0002-2920-212X
Paloma Poza-GuedesAllergy Department, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Tenerife, Spain.ORCID 0000-0001-8516-6648
Olaia SardónDivision of Pediatric Respiratory Medicine, Hospital Universitario Donostia, San Sebastián, Spain.
Paula CorcueraDivision of Pediatric Respiratory Medicine, Hospital Universitario Donostia, San Sebastián, Spain.ORCID 0000-0001-8661-7033
Greg A HawkinsDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Annalisa MarsicoComputational Health Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
Thomas BahmerLungenClinic Grosshansdorf, Pneumology, Grosshansdorf, Germany.
Klaus F RabeLungenClinic Grosshansdorf, Pneumology, Grosshansdorf, Germany.
Gesine HansenDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Matthias Volkmar KoppDivision of Pediatric Pneumology & Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany.
Raimon RiosPrograma de Pós Graduação em Imunologia (PPGIm), Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, Brazil.
Maria Jesus CruzCIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Francisco-Javier González-BarcalaServicio de Neumología, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.
José María OlaguibelCIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.ORCID 0000-0002-9126-4559
Vicente PlazaCIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.ORCID 0000-0003-2567-5496
Santiago QuirceCIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.ORCID 0000-0001-8086-0921
Glorisa CaninoBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Michelle CloutierDepartment of Pediatrics, University of Connecticut, Farmington, Connecticut, USA.ORCID 0000-0001-8316-6409
Victoria Del PozoCIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.ORCID 0000-0001-6228-1969
Jose R Rodriguez-SantanaCentro de Neumología Pediátrica, San Juan, Puerto Rico.
Javier Korta-MuruaDepartment of Pediatrics, University of the Basque Country (UPV/EHU), San Sebastián, Spain.
Jesús VillarCIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Uroš PotočnikLaboratory for Biochemistry, Molecular Biology and Genomics, Faculty for Chemistry and Chemical Engineering, University of Maribor, Maribor, Slovenia.
Camila FigueiredoInstituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.ORCID 0000-0003-1356-6188
Michael KabeschDepartment of Paediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
Somnath MukhopadhyayAcademic Department of Paediatrics, Brighton and Sussex Medical School, Royal Alexandra Children's Hospital, Brighton, UK.
Munir PirmohamedDepartment of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID 0000-0002-7534-7266
Daniel B HawcuttDepartment of Women's and Children's Health, University of Liverpool, Liverpool, UK.ORCID 0000-0002-8120-6507
Erik MelénDepartment of Clinical Sciences and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-8248-0663
Colin N PalmerPopulation Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.ORCID 0000-0002-6415-6560
Steve TurnerChild Health, University of Aberdeen, Aberdeen, UK.ORCID 0000-0001-8393-5060
Anke H Maitland-van der ZeeDepartment of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-0414-3442
Erika von MutiusInstitute for Asthma and Allergy Prevention, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.ORCID 0000-0002-8893-4515
Juan C CeledónDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-6139-5320
Guy BrusselleDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-7021-8505
Fook Tim ChewDepartment of Biological Sciences, National University of Singapore, Singapore City, Singapore.ORCID 0000-0003-1337-5146
Eugene BleeckerDivision of Genetics, Genomics, and Precision Medicine, Department of Internal Medicine, University of Arizona College of Medicine, Tucson, Arizona, USA.
Deborah MeyersDivision of Genetics, Genomics, and Precision Medicine, Department of Internal Medicine, University of Arizona College of Medicine, Tucson, Arizona, USA.
Esteban G BurchardSevere Asthma Unit, Allergy Department, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Tenerife, Spain.ORCID 0000-0001-7475-2035
Maria Pino-YanesGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), San Cristóbal de La Laguna, Tenerife, Spain.ORCID 0000-0003-0332-437X
Universidad de La Laguna · ESUniversity of Liverpool · GBUniversity of Pittsburgh · USUniversity of the Basque Country · ESHelmholtz Zentrum München · DEUniversidade Federal da Bahia · BRUniversity of Arizona · USUtrecht University · NLAmsterdam University Medical Centers · NLBrighton and Sussex Medical School · GBComplejo Hospitalario Universitario de Santiago · ESGhent University Hospital · BEHospital de Sant Pau · ESHospital Universitario de Canarias · ESNational University of Singapore · SGUniversity of Bern · CHUniversity of California, San Francisco · USUniversity of Connecticut · USBiogipuzkoa Health Research Institute · ESCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ES
Funding
Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1MThe Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3MSocial Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHILLINGER, DEAN · 2012 to 2016
$6.4MGene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4MSF BUILD: Enabling Students to Represent in ScienceRL5GM118984 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2023
$5.2MOptimizing imputation for diverse populations in a distributed frameworkU01HG009080 · NHGRI · STANFORD UNIVERSITY · PI KENNY, EIMEAR ELIZABETH · 2016 to 2020
$5.2MTranscriptomic and Pharmacogenetic Asthma Endotypes in Minority ChildrenR01HL135156 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A, ZIV, ELAD · 2017 to 2021
$4.1MGenes, air pollution, and asthma severity in minority childrenR01MD010443 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEIBOLD, MAX A, ZIV, ELAD · 2016 to 2020
$3.8MEffects of Rare Variants and Ancestry on Beta Agonist Response in Asthma and COPDR01HL142992 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ORTEGA, VICTOR E. · 2019 to 2023
$3.7MLeveraging electronic medical records to perform large-scale diabetes pharmacogenomics among ancestrally diverse patient populationsR01DK113003 · NIDDK · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2017 to 2021
$3.2MGenetic Control of Airway Epithelium Gene Expression in Childhood AsthmaticsR01HL128439 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2015 to 2019
$3.1MPoly-omic Study of Asthma Exacerbations in Diverse PopulationsR01HL141845 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2019 to 2022
$3.0MMedical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MR/L006758/1NCATS NIH HHS UL1 TR001872NHGRI NIH HHS U01 HG009080NHLBI NIH HHS K01 HL138098NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL128439NHLBI NIH HHS R01 HL135156NHLBI NIH HHS R01 HL141845NHLBI NIH HHS R01 HL141992NHLBI NIH HHS R01 HL142992NHLBI NIH HHS R01 HL155024NIDDK NIH HHS R01 DK113003NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIGMS NIH HHS RL5 GM118984NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443NIMHD NIH HHS R56 MD013312Wellcome TrustWellcome Trust 099177/Z/12/ZWellcome Trust 102215/2/13/2
Abstract
backgroundAsthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied in several populations, but no prior study has performed a multi-ancestry meta-analysis of genome-wide association studies (meta-GWAS) for this trait. We aimed to identify common genetic loci associated with asthma exacerbations across diverse populations and to assess their functional role in regulating DNA methylation and gene expression.
methodsA meta-GWAS of asthma exacerbations in 4989 Europeans, 2181 Hispanics/Latinos, 1250 Singaporean Chinese, and 972 African Americans analyzed 9.6 million genetic variants. Suggestively associated variants (p ≤ 5 × 10
resultsOne hundred and twenty-six independent variants were suggestively associated with asthma exacerbations in the discovery phase. Two variants independently replicated: rs12091010 located at vascular cell adhesion molecule-1/exostosin like glycosyltransferase-2 (VCAM1/EXTL2) (discovery: odds ratio (OR
conclusionsThis multi-ancestry study revealed novel suggestive regulatory loci for asthma exacerbations located in genomic regions participating in inflammation and host defense.
Indexed as
AsthmaGenome-Wide Association StudyGenetic Predisposition to DiseaseHispanic or LatinoHumansPolymorphism, Single NucleotideQuality of Lifeasthma exacerbationsEXTL2GWASPANK1single-nucleotide polymorphism
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