Evidence map›Paper›PMID 35753960›Full record

ArticleTrends in cell biology2022

Nonredundant Rac-GEF control of actin cytoskeleton reorganization.

Marcelo G Kazanietz, Mariana Cooke, Rafael Garcia-Mata

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. RAC1 signaling in prostate cancer: VAV GEFs take center stage.Frontiers in cell and developmental biology · 2025
    Article
  4. Apoptosis regulation by the tyrosine-protein kinase CSK.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Marcelo G KazanietzDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: marcelog@pennmedicine.upenn.edu.
Mariana CookeDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Einstein Medical Center Philadelphia, Philadelphia, PA 19141, USA.
Rafael Garcia-MataDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA. Electronic address: rafael.garciamata@utoledo.edu.
University of Pennsylvania · USUniversity of Toledo · US

Funding

Protein kinase C and lung carcinogenesisR01ES026023 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI KAZANIETZ, MARCELO G. · 2015 to 2019
$2.3M
Effectors of protein kinase C-mediated tumor progressionR01CA196232 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KAZANIETZ, MARCELO G. · 2016 to 2022
$2.0M
Regulation of epithelial junctions and lumen morphogenesis by the Scribble/SGEF/Dlg1 complexR01GM136826 · NIGMS · UNIVERSITY OF TOLEDO · PI GARCIA-MATA, RAFAEL · 2020 to 2023
$1.5M
Identification of novel regulators of invadopodia formationR03CA234693 · NCI · UNIVERSITY OF TOLEDO · PI GARCIA-MATA, RAFAEL · 2019 to 2020
$150k
NCI NIH HHS R01 CA196232NCI NIH HHS R03 CA234693NIEHS NIH HHS R01 ES026023NIGMS NIH HHS R01 GM136826
6 · The paper itself

Abstract

Rac-GEFs operate in a nonredundant manner as downstream effectors of receptor tyrosine kinases to promote ruffle formation, indicative of unique modes of regulation and targeting. Current research is shedding light on the intricate signaling paradigms shaping spatiotemporal activation of the small GTPase Rac during the generation of actin-rich membrane protrusions.

Indexed as

ActinsSignal TransductionActin CytoskeletonHumansActinsactin cytoskeletoncancerRacRac-GEFsrufflessmall GTPases

Identifiers

PMID35753960
PMCPMC9930409
OpenAlexW4283370648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.