Evidence map›Paper›PMID 35753395›Full record

Observational studyThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Characteristics and management of children with Clostridioides difficile infection at a tertiary pediatric hospital in China.

Xiaolu Li, Fangfei Xiao, Youran Li, Hui Hu, Yongmei Xiao, Qiao Xu, Dan Li, Guangjun Yu, Yizhong Wang, Ting Zhang

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Gut Microbial and Metabolic Features Associated WithOpen forum infectious diseases · 2024
    Article
  3. Antimicrobial Resistance ofInfection and drug resistance · 2024
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xiaolu LiShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of Gastroenterology, Hepatology and Nutrition, Shanghai, China.
Fangfei XiaoShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of Gastroenterology, Hepatology and Nutrition, Shanghai, China.
Youran LiShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of Gastroenterology, Hepatology and Nutrition, Shanghai, China.
Hui HuShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of Gastroenterology, Hepatology and Nutrition, Shanghai, China.
Yongmei XiaoShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of Gastroenterology, Hepatology and Nutrition, Shanghai, China.
Qiao XuShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of Gastroenterology, Hepatology and Nutrition, Shanghai, China.
Dan LiShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of Gastroenterology, Hepatology and Nutrition, Shanghai, China.
Guangjun YuShanghai Jiao Tong University, School of Medicine, Institute of Pediatric Infection, Immunity and Critical Care Medicine, Shanghai, China.
Yizhong WangShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of Gastroenterology, Hepatology and Nutrition, Shanghai, China; Shanghai Jiao Tong University, School of Medicine, Institute of Pediatric Infection, Immunity and Critical Care Medicine, Shanghai, China. Electronic address: wangyz@shchildren.com.cn.
Ting ZhangShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of Gastroenterology, Hepatology and Nutrition, Shanghai, China; Shanghai Jiao Tong University, School of Medicine, Institute of Pediatric Infection, Immunity and Critical Care Medicine, Shanghai, China. Electronic address: zhangt@shchildren.com.cn.
Shanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClostridiodes difficile infection (CDI) is one of the most common causes of antibiotic-associated diarrhea in children. Conventional antibiotics and emerging fecal microbiota transplantation (FMT) are used to treat CDI.

methodsChildren with CDI admitted to the Shanghai Children's Hospital, from September 2014 to September 2020, were retrospectively included to this observational study. Pediatric patients were assigned as initial CDI and recurrent CDI (RCDI), and symptoms, comorbidities, imaging findings, laboratory tests, and treatments were systematically recorded and analyzed.

resultsOf 109 pediatric patients with CDI, 58 were boys (53.2%), and the median age was 5 years (range, 2-9 years). The main clinical symptoms of CDI children were diarrhea (109/109, 100%), hematochezia (55/109, 50.46%), abdominal pain (40/109, 36.70%); fever, pseudomembrane, vomit, and bloating were observed in 39 (35.78%), 33 (30.28%), and 24 (22.02%) patients, respectively. For the primary therapy with conventional antibiotics, 68 patients received metronidazole, and 41 patients received vancomycin. RCDI occurred in 48.53% (33/68) of those initially treated with metronidazole compared with 46.33% (19/41) of those initially treated with vancomycin (p=0.825). The total resolution rate of FMT for RCDI children was significantly higher than with vancomycin treatment (28/29, 96.55% vs 11/23, 47.83%, p < 0.001). There were no serious adverse events (SAEs) reported after two months of FMT.

conclusionsThe major manifestations of children with CDI were diarrhea, hematochezia, and abdominal pain. The cure rate of FMT for pediatric RCDI is superior to vancomycin treatment.

Indexed as

Clostridioides difficileClostridium InfectionsAbdominal PainAnti-Bacterial AgentsChildChild, PreschoolChinaDiarrheaFemaleGastrointestinal HemorrhageHospitals, PediatricHumansMaleMetronidazoleRecurrenceRetrospective StudiesAnti-Bacterial AgentsMetronidazoleVancomycinAntibioticChildrenClostridiodes difficile infectionFecal microbiota transplantationVancomycin

Identifiers

PMID35753395
PMCPMC9459065
OpenAlexW4283360676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.