Evidence map›Paper›PMID 35753108›Full record

ReviewCurrent opinion in neurobiology2022

Linking external stimuli with internal drives: A role for the ventral hippocampus.

Victoria S Turner, Rachel O O'Sullivan, Mazen A Kheirbek

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Survey of Hippocampal Responses to Sound in Naive Mice Reveals Widespread Activation by Broadband Noise Onsets.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  11. Article
  12. Anxiety and Beyond: Diversity in Ventral Hippocampus Circuits and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Identifying dysfunctional cell types and circuits in animal models for psychiatric disorders with calcium imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Victoria S TurnerNeuroscience Graduate Program, University of California, San Francisco, USA. Electronic address: https://twitter.com/vs_turner.
Rachel O O'SullivanNeuroscience Graduate Program, University of California, San Francisco, USA. Electronic address: https://twitter.com/itsROsulli.
Mazen A KheirbekNeuroscience Graduate Program, University of California, San Francisco, USA; Department of Psychiatry and Behavioral Sciences, Kavli Institute for Fundamental Neuroscience and Weill Institute for Neurosciences, University of California, San Francisco, USA. Electronic address: mazen.kheirbek@ucsf.edu.

Funding

Hippocampal modulation of subcortical circuits in the control of emotional behaviorR01MH108623 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mazen A Kheirbek · 2016 to 2026
$6.0M
Predoctoral Training in NeurobiologyT32NS115706 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAMUEL JEREMY PLEASURE · 2020 to 2026
$3.4M
Circuit dynamics supporting associative learning in the dentate gyrusR01DC019813 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A · 2021 to 2025
$2.8M
How is anxiety-related information relayed across hippocampal-prefrontal circuitsR01MH117961 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A, SOHAL, VIKAAS SINGH · 2019 to 2022
$2.3M
Circuit and cellular mechanisms of adult neurogenesis in context encoding and discriminationR01MH111754 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A · 2017 to 2021
$2.0M
NIDCD NIH HHS R01 DC019813NIMH NIH HHS R01 MH108623NIMH NIH HHS R01 MH111754NIMH NIH HHS R01 MH117961NINDS NIH HHS T32 NS115706
6 · The paper itself

Abstract

The ventral hippocampus (vHPC) has long been thought of as the "emotional" hippocampus. Over the past several years, the complexity of vHPC has come to light, highlighting the diversity of cell types, inputs, and outputs that coordinate a constellation of positively and negatively motivated behaviors. Here, we review recent work on how vCA1 contributes to a network that associates external stimuli with internal motivational drive states to promote the selection of adaptive behavioral responses. We propose a model of vHPC function that emphasizes its role in the integration and transformation of internal and external cues to guide behavioral selection when faced with multiple potential outcomes.

Indexed as

Hippocampus

Identifiers

PMID35753108
PMCPMC9818033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.