ArticleNeurourology and urodynamics2022
THE CASE AGAINST urethral failure is not a critical factor in female urinary incontinence. Now what? The integral theory system.
Article in Neurourology and urodynamics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 8 citations in OpenAlex.
- Comparing combined paravaginal repair with pubocervical fascia plication versus standard anterior colporrhaphy for the treatment of stress urinary incontinence in women with anterior vaginal wall prolapse: a randomised controlled trial.Archives of gynecology and obstetrics · 2025Trial
- Regenerative Medicine Approaches to Stress Urinary Incontinence.Biomimetics (Basel, Switzerland) · 2026Review
- Short-Term Success Rate and Risk Factors for Failure of the Urethral Plication Procedure in the Management of Post-Obstetric Fistula Closure Stress Urinary Incontinence Among Ugandan Women: A Prospective Cohort Study.International journal of women's health · 2026Article
- Fluid intake schedule as a possible risk-stratification factor for urinary incontinence in women during menopause.Przeglad menopauzalny = Menopause review · 2025Article
- Neuromodulation Improves Stress Urinary Incontinence-Like Deficits in Female Rabbits.IEEE open journal of engineering in medicine and biology · 2025Article
- The Integral Theory, Pelvic Floor Biomechanics, and Binary Innervation.International neurourology journal · 2024Article
- Urethral failure is not the predominant cause of female stress urinary incontinence.Neurourology and urodynamics · 2023Article
- Reply to: The case against urethral failure is not a critical factor in female urinary incontinence. Now what? The integral theory system.Neurourology and urodynamics · 2022Article
- THE CASE AGAINST urethral failure is not a critical factor in female urinary incontinence. Now what? The integral theory system.Neurourology and urodynamics · 2022Article
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Authors and funding
1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
subject of the debate"Urethral failure is a critical factor in female urinary incontinence Now what?" The CASE FOR by Hokanson, DeLancey pinpointed inadequacy of bladder causation for urgency urinary incontinence (UUI) and poor urethral support for stress urinary incontinence (SUI) as responsible for long-standing lack of progress in incontinence science. They proposed "Urethral failure" as causation for SUI and UUI. The CASE AGAINST, by Peter Petros agrees "abnormal detrusor function as cause for (UUI) is a failed concept, and SUI surgery results are sometimes suboptimal, but rejects "urethral failure" as cause for UUI and SUI. In answer to, "Now what?," Petros presents the Integral Theory System. SUI and UUI are dysfunctions of the bladder's binary control mechanism, mainly ligament laxity because of defective collagen/elastin. The urethra is an emptying tube. Pelvic muscle forces reflexly contract against ligaments to close urethra, open it (micturition) and stretch the vagina underlying urethelial stretch receptors to mechanically support them, preventing premature activation of micturition (UUI). High validated cure rates for SUI and UUI by repair of weakened ligaments question viability of the "urethral failure" concept.
conclusionsThe major achievement of this debate (both sides) is not what causes UUI or SUI, or what doesn't, though clearly, this is important. It is calling out a 50-year ossification of the whole construct of UUI, ranging from flawed definitions to systematic denial of known cures, all of which have stalled treatment of the one billion women who suffer with incontinence. The time has come for change.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.