ArticleMolecular biology reports2022
The different effects of intramuscularly-injected lactate on white and brown adipose tissue in vivo.
Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Lactate: elucidating its indispensable role in human health.Molecular cancer · 2026Review
- Mechanism of Fatty Acid Metabolism and Regulation by Lactate During Exercise in White Adipose and Skeletal Muscle Tissue: A Review.Sports medicine - open · 2025Review
- Metabolic Activity in Human Intermuscular Adipose Tissue Directs the Response of Resident PPARγBiomedicines · 2024Article
- Deciphering the Therapeutic Role of Lactate in Combating Disuse-Induced Muscle Atrophy: An NMR-Based Metabolomic Study in Mice.Molecules (Basel, Switzerland) · 2024Article
- The effects of long-term lactate and high-intensity interval training (HIIT) on brain neuroplasticity of aged mice.Heliyon · 2024Article
- The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions.Nature metabolism · 2023Article
- Standardized Ethanol Extract ofNutrients · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLactate is an important product of glycolysis metabolism during exercise and has long been recognized as an important metabolic signaling molecule involved in inhibiting lipolysis and promoting lipogenesis, which consequently leads to regulated adipose tissue metabolism. However, recent studies have shown that lactate promotes the browning of white adipose tissue (WAT), which induces heat production and energy expenditure and ultimately causes weight loss. These studies assessing the effects of lactate on lipid metabolism in adipose tissue have revealed conflicting data, making it an important area worthy of further research.
methodsIn this study, using intramuscular injection of lactate to the gastrocnemius, we identified the role of lactate treatment on lipid metabolism and mitochondrial biogenesis of white adipose tissue and brown adipose tissue (BAT).
resultsOur results showed that lactate treatment activated the cAMP/PKA signaling pathway and promoted the expression of lipolysis-related proteins (AMPK, HSL, ATGL) and mitochondrial biomarkers (PGC-1α, COXIV) of WAT, while BAT showed an opposite trend after lactate treatment. Further studies showed that lactate treatment significantly increased serum epinephrine and promoted β3-AR protein expression in WAT and significantly decreased in BAT.
conclusionOur study shows that lactate seems to regulate β3-adrenergic receptors differently in WAT and BAT, thereby eliciting disparate responses in adipose tissue.
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Registered trials
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