ArticleBMC complementary medicine and therapies2022
Anti-melanogenesis effect from Wampee fruit pectin via α-MSH/TRY pathway in A375 cells.
Article in BMC complementary medicine and therapies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Biological Roles of Melanin and Natural Product-Derived Approaches for Its Modulation.International journal of molecular sciences · 2026Review
- The effect of broccoli stem extract cream (Frontiers in medicine · 2025Article
- Study on the Chemical Composition and Anti-Tumor Mechanisms ofFoods (Basel, Switzerland) · 2024Article
- Molecular understanding of the therapeutic potential of melanin inhibiting natural products.RSC medicinal chemistry · 2024Review
- Anti-Melanogenesis Effect of Polysaccharide fromNutrients · 2022Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPolysaccharides from wampee have been reported to process various biological activities, while the relationship between structure and bioactivities has been barely addressed. Pectin, an abundant water-soluble polysaccharide in wampee, showed significant antioxidant activity, which was associated with the anti-melanogenic activity. Therefore, this study investigated the physicochemical characteristics and the anti-melanogenesis effect of pectin extracted from wampee fruit in A375 cells.
methodsThe physicochemical characterization of pectin from wampee fruit was investigated by gel chromatography (GCP), FT-IR spectroscopy, and NMR spectroscopy methods. The anti-melanogenesis effects and mechanism were evaluated by mushroom tyrosine enzyme and human melanin cell model in vitro.
resultsThe results showed that a molecular weight of 5.271 × 10
conclusionThese results indicated that WFP could inhibit α-MSH induced melanogenesis in A375 melanoma cells via α-MSH/TRY pathway. In conclusion, these data provided a new perspective to annotate WFP anti-melanogenesis activity mechanism.
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