ArticleThe journal of headache and pain2022
Repeated inflammatory dural stimulation-induced cephalic allodynia causes alteration of gut microbial composition in rats.
Article in The journal of headache and pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Gut microbiota, probiotics, and migraine: a clinical review and meta-analysis.Journal of oral & facial pain and headache · 2025Pooled it
- Sex differences in behaviors, neuronal activation, and gut-microbiota-metabolic axis in a repeated nitroglycerin-induced chronic migraine model.The journal of headache and pain · 2026Article
- Electroacupuncture alleviates migraine through CXCL13/CXCR5-mediated communication.Chinese medicine · 2026Article
- The microgenderome in migraine: integrating sex hormones, microbial composition, and metabolic profiles into a sex-related framework.Frontiers in microbiology · 2026Review
- Integrated Multi-Omics Analyses Identify Acupuncture-Associated Changes in Gut Microbiota, Short-Chain Fatty Acids, and TNC Gene Expression in Chronic Migraine Rats.Journal of inflammation research · 2026Article
- Acupuncture Alleviates Neuroinflammation in Chronic Migraine by Modulating Lactobacillus and Its Metabolite Pathways.Pain research & management · 2026Article
- The Effect of Ambient Temperature on Migraine Disease: A Scoping Review.Brain and behavior · 2025Article
- Transcutaneous occipital nerve stimulation alleviated migraine related pain by regulating synaptic plasticity and CGRP expression in the periaqueductal gray of male rats.The journal of headache and pain · 2025Article
- The Gut Microbiome and Migraine: Updates in Understanding.Current neurology and neuroscience reports · 2025Review
- The Mechanism of Acupuncture Therapy for Migraine: A Systematic Review of Animal Studies on Rats.Journal of pain research · 2025Review
- A Narrative Review of Intestinal Microbiota's Impact on Migraine with Psychopathologies.International journal of molecular sciences · 2024Review
- Alleviation of migraine related pain and anxiety by inhibiting calcium-stimulating AC1-dependent CGRP in the insula of adult rats.The journal of headache and pain · 2024Article
- To analyze the relationship between gut microbiota, metabolites and migraine: a two-sample Mendelian randomization study.Frontiers in microbiology · 2024Article
- A causal effects of gut microbiota in the development of migraine.The journal of headache and pain · 2023Article
- A Bibliometric and Scientific Knowledge Map Study of Migraine Treatment from 2013 to 2022.Journal of pain research · 2023Article
- Integrated 16S rRNA sequencing and metabolomics analysis to investigate the antidepressant role of Yang-Xin-Jie-Yu decoction on microbe-gut-metabolite in chronic unpredictable mild stress-induced depression rat model.Frontiers in pharmacology · 2022Article
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Authors and funding
11 authors at 3 institutions in 1 country.
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Abstract
backgroundGut microbial dysbiosis and gut-brain axis dysfunction have been implicated in the pathophysiology of migraine. However, it is unclear whether migraine-related cephalic allodynia could induce the alteration of gut microbial composition.
methodsA classic migraine rat model was established by repeated dural infusions of inflammatory soup (IS). Periorbital mechanical threshold and nociception-related behaviors were used to evaluate IS-induced cephalic allodynia and the preventive effect of topiramate. The alterations in gut microbial composition and potential metabolic pathways were investigated based on the results of 16 S rRNA gene sequencing. Microbiota-related short-chain fatty acids and tryptophan metabolites were detected and quantified by mass spectrometry analysis.
resultsRepeated dural IS infusions induced cephalic allodynia (decreased mechanical threshold), migraine-like behaviors (increased immobility time and reduced moving distance), and microbial composition alteration, which were ameliorated by the treatment of topiramate. Decreased Lactobacillus was the most prominent biomarker genus in the IS-induced alteration of microbial composition. Additionally, IS infusions also enhanced metabolic pathways of the gut microbiota in butanoate, propanoate, and tryptophan, while the increased tryptophan-related metabolites indole-3-acetamide and tryptophol in feces could be the indicators.
conclusionsInflammatory dural stimulation-induced cephalic allodynia causes the alterations of gut microbiota profile and microbial metabolic pathways.
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