Evidence map›Paper›PMID 35752761›Full record

ArticleBMC cardiovascular disorders2022

Effect of single ventricular premature contractions on response to cardiac resynchronization therapy.

Eperke Dóra Merkel, András Mihaly Boros, Walter Richárd Schwertner, Anett Behon, Attila Kovács, Bálint Károly Lakatos, László Gellér, Annamária Kosztin, Béla Merkely

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In one paragraph

Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Eperke Dóra MerkelHeart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, 1122, Hungary.
András Mihaly BorosHeart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, 1122, Hungary.
Walter Richárd SchwertnerHeart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, 1122, Hungary.
Anett BehonHeart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, 1122, Hungary.
Attila KovácsHeart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, 1122, Hungary.
Bálint Károly LakatosHeart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, 1122, Hungary.
László GellérHeart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, 1122, Hungary.
Annamária Kosztin *Heart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, 1122, Hungary.
Béla Merkely *Heart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, 1122, Hungary. merkely.study@gmail.com.
Semmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe lack data on the effect of single premature ventricular contractions (PVCs) on the clinical and echocardiographic response after cardiac resynchronization therapy (CRT) device implantation. We aimed to assess the predictive value of PVCs at early, 1 month-follow up on echocardiographic response and all-cause mortality.

methodsIn our prospective, single-center study, 125 heart failure patients underwent CRT implantation based on the current guidelines. Echocardiographic reverse remodeling was defined as a ≥ 15% improvement in left ventricular ejection fraction (LVEF), end-systolic volume (LVESV), or left atrial volume (LAV) measured 6 months after CRT implantation. All-cause mortality was investigated by Wilcoxon analysis.

resultsThe median number of PVCs was 11,401 in those 67 patients who attended the 1-month follow-up. Regarding echocardiographic endpoints, patients with less PVCs develop significantly larger LAV reverse remodeling compared to those with high number of PVCs. During the mean follow-up time of 2.1 years, 26 (21%) patients died. Patients with a higher number of PVCs than our median cut-off value showed a higher risk of early all-cause mortality (HR 0.97; 95% CI 0.38-2.48; P = 0.04). However, when patients were followed up to 9 years, its significance diminished (HR 0.78; 95% CI 0.42-1.46; P = 0.15).

conclusionsIn patients undergoing CRT implantation, lower number of PVCs predicted atrial remodeling and showed a trend for a better mortality outcome. Our results suggest the importance of the early assessment of PVCs in cardiac resynchronization therapy and warrant further investigations.

Indexed as

Cardiac Resynchronization TherapyHeart FailureVentricular Premature ComplexesHumansProspective StudiesStroke VolumeTreatment OutcomeVentricular Function, LeftVentricular RemodelingAll-cause mortalityCardiac resynchronization therapyPremature ventricular contractionsReverse remodeling

Identifiers

PMID35752761
PMCPMC9233778
OpenAlexW4283462488

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.