Evidence map›Paper›PMID 35752729›Full record

ArticleJournal of autism and developmental disorders2023

Distinct Symptom Network Structure and Shared Central Social Communication Symptomatology in Autism and Schizophrenia: A Bayesian Network Analysis.

Gloria T Han, Dominic A Trevisan, Jennifer Foss-Feig, Vinod Srihari, James C McPartland

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05837988 (Construction of Symptom Network in Maintenance Hemodialysis Patients), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05837988 unknown statusnot on this map

Construction of Symptom Network in Maintenance Hemodialysis Patients

TypeobservationalSponsorRenJi HospitalRan2023 to 2025Enrolled517ConditionsSymptom Cluster, Symptoms and Signs, Hemodialysis Complication, Hemodialysis-Associated Pruritus
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. The Network Model of Mentalization, Social Vulnerability, and the Self in Autism: A Comparison With Neurotypical Adults.Autism research : official journal of the International Society for Autism Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gloria T HanYale School of Medicine, New Haven, CT, USA. gloria.han@yale.edu.ORCID http://orcid.org/0000-0002-4818-983X
Dominic A TrevisanYale School of Medicine, New Haven, CT, USA.
Jennifer Foss-FeigIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Vinod SrihariYale School of Medicine, New Haven, CT, USA.
James C McPartlandYale School of Medicine, New Haven, CT, USA. james.mcpartland@yale.edu.
Yale University · USIcahn School of Medicine at Mount Sinai · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The Autism Biomarkers Consortium for Clinical TrialsU19MH108206 · NIMH · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES · 2015 to 2024
$68.8M
PROMIS-guided development and validation of a dimensional observer-report measure of positive and negative features of ASDR01MH119172 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FOSS-FEIG, JENNIFER · 2019 to 2023
$4.1M
TIPS: Training in Perioperative ScienceT32GM108554 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire · 2014 to 2026
$3.7M
Multimodel Assessment of Social Process Systems across Neurodevelopmental DisordersR01MH107426 · NIMH · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES, SRIHARI, VINOD H. · 2015 to 2017
$651k
NCATS NIH HHS UL1 TR001863NIGMS NIH HHS T32 GM108554NIMH NIH HHS R01 MH107426NIMH NIH HHS R01 MH119172NIMH NIH HHS U19 MH108206
6 · The paper itself

Abstract

Autism (ASD) and schizophrenia spectrum disorders (SCZ) are neurodevelopmental conditions with overlapping and interrelated symptoms. A network analysis approach that represents clinical conditions as a set of "nodes" (symptoms) connected by "edges" (relations among symptoms) was used to compare symptom organization in the two conditions. Gaussian graphical models were estimated using Bayesian methods to model separate symptom networks for adults with confirmed ASD or SCZ diagnoses. Though overall symptom organization differed by diagnostic group, both symptom networks demonstrated high centrality of social communication difficulties. Autism-relevant restricted and repetitive behaviors and schizophrenia-related cognitive-perceptual symptoms were uniquely central to the ASD and SCZ networks, respectively. Results offer recommendations to improve differential diagnosis and highlight potential treatment targets in ASD and SCZ.

Indexed as

Autism Spectrum DisorderAutistic DisorderSchizophreniaAdultBayes TheoremCommunicationHumansAutismNetwork analysisSchizophreniaSocial communication

Identifiers

PMID35752729
PMCPMC10202012
OpenAlexW4283459275

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.