ArticleJournal of perinatology : official journal of the California Perinatal Association2022
Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- A FAR-Out approach for evaluating the impact of clinical practice changes on severe intracranial hemorrhage in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Prophylactic indomethacin and the risk of serious pulmonary hemorrhages in preterm infants less than 28 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Pathogenesis and Prevention of Intraventricular Hemorrhage in Preterm Infants.Journal of Korean Neurosurgical Society · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify the relationship between prophylactic indomethacin (PI) administration and incidence of intraventricular hemorrhage. STUDY
designA retrospective analysis of extremely premature infants <27 weeks gestational age born between January 2014 and September 2020.
resultsA total of 421 infants were included from three of Nationwide Children's Hospital delivery centers. Of those 255 (61%) received PI. After adjustment by inverse proportionality treatment weighting (IPTW), no differences were found in incidence of intraventricular hemorrhage (IVH) at the time of the first ultrasound, 31% vs. 33% in PI and control groups respectively (p = 0.68). The rate of rise of serum creatinine from baseline to day of life four was significantly higher in the PI group (0.14 mg/dl PI and 0.03 mg/dl control, p < 0.001).
conclusionPI was not associated with any benefit in prevention of IVH, but is associated with adverse effects including acute rise in creatinine.
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Registered trials
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