Evidence map›Paper›PMID 35752213›Full record

ArticleJournal of molecular biology2022

A Slow Dynamic RNA Switch Regulates Processing of microRNA-21.

Matthew D Shortridge, Greg L Olsen, Wen Yang, Matthew J Walker, Gabriele Varani

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Structure of pre-miR-31 reveals an active role in Dicer-TRBP complex processing.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. Article
  6. Structure of pre-miR-31 reveals an active role in Dicer processing.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Matthew D ShortridgeDepartment of Chemistry, University of Washington, Seattle, WA 98195-1700, USA.
Greg L OlsenDepartment of Chemistry, University of Washington, Seattle, WA 98195-1700, USA.
Wen YangDepartment of Chemistry, University of Washington, Seattle, WA 98195-1700, USA; Greater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen, Guangdong Province 518036, China.
Matthew J WalkerDepartment of Chemistry, University of Washington, Seattle, WA 98195-1700, USA; Neoleukin Therapeutics, 188 East Blaine St, Suite 450, Seattle, WA 98102, USA.
Gabriele VaraniDepartment of Chemistry, University of Washington, Seattle, WA 98195-1700, USA. Electronic address: varani@chem.washington.edu.
University of Washington · USShenzhen Bay Laboratory · CN

Funding

ncRNA: Structure, Interactions and InhibitionR35GM126942 · NIGMS · UNIVERSITY OF WASHINGTON · PI Gabriele Varani · 2018 to 2026
$6.0M
Regulation of microRNA processingR01GM103834 · NIGMS · UNIVERSITY OF WASHINGTON · PI VARANI, GABRIELE · 2014 to 2017
$1.1M
NIGMS NIH HHS R01 GM103834NIGMS NIH HHS R35 GM126942
6 · The paper itself

Abstract

The microRNAs are non-coding RNAs which post-transcriptionally regulate the expression of many eukaryotic genes, and whose dysregulation is a driver of human disease. Here we report the discovery of a very slow (0.1 s

Indexed as

MicroRNAsRiboswitchRNA Processing, Post-TranscriptionalRNA StabilityHumansLigandsNucleic Acid ConformationRibonuclease IIIRNA CleavageLigandsMicroRNAsMIRN21 microRNA, humanRibonuclease IIIRiboswitchdynamicsmiRNA biogenesisNMRpre-miR-21regulation

Identifiers

PMID35752213
PMCPMC10593484
OpenAlexW4283331191

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.