Evidence map›Paper›PMID 35752065›Full record

ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2022

Monte Carlo study of metabolite correlations originating from spectral overlap.

Sungtak Hong, Li An, Jun Shen

Abstract read
In one paragraph

Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. A data-driven algorithm to determineMagnetic resonance in medicine · 2026
    Article
  2. Article
  3. Metabolic coupling between glutamate and N-acetylaspartate in the human brain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sungtak HongNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. Electronic address: sungtak.hong@nih.gov.
Li AnNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. Electronic address: li.an@nih.gov.
Jun ShenNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. Electronic address: jun.shen@nih.gov.

Funding

Magnetic Resonance Spectroscopy and Imaging Studies of Brain FunctionsZIAMH002803 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SHEN, JUN · 2009 to 2025
$24.9M
MRS and Imaging Studies of Brain FunctionsZ01MH002803 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SHEN, JUN · 2003 to 2008
$1.8M
Intramural NIH HHS Z01 MH002803Intramural NIH HHS ZIA MH002803
6 · The paper itself

Abstract

Monte Carlo simulations and a mathematical model of spectral fitting were used to study the correlations between metabolites with overlapping resonances. The dependence of the polarity and the magnitude of cross-correlation coefficients between overlapping metabolites on the spectral patterns of MRS signals was investigated. The results demonstrate the importance of quantifying metabolite correlations originating from spectral overlap as they may confound determination of correlations of biological origin. The findings also indicate that it is possible to minimize unwanted metabolite correlations by altering spectral patterns in the presence of significant spectral overlap.

Indexed as

Models, TheoreticalComputer SimulationMonte Carlo MethodCross-correlationDensity matrix simulationGlutamateMonte Carlo simulationN-acetylaspartate

Identifiers

PMID35752065
PMCPMC9339476

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.