Evidence map›Paper›PMID 35751864›Full record

ArticleMedical physics2022

Regional left ventricular endocardial strains estimated from low-dose 4DCT: Comparison with cardiac magnetic resonance feature tracking.

Ashish Manohar, Gabrielle M Colvert, Juan E Ortuño, Zhennong Chen, James Yang, Brendan T Colvert, W Patricia Bandettini, Marcus Y Chen, María J Ledesma-Carbayo, Elliot R McVeigh

Open access · greenAbstract read
In one paragraph

Article in Medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Advanced myocardial characterization and function with cardiac CT.The international journal of cardiovascular imaging · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. 3D regional evaluation of right ventricular myocardial work from cineCT.medRxiv : the preprint server for health sciences · 2024
    Article
  7. Review
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Ashish ManoharDepartment of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, California, USA.
Gabrielle M ColvertDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA.
Juan E OrtuñoBiomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine, Madrid, Spain.
Zhennong ChenDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA.
James YangDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA.
Brendan T ColvertDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA.
W Patricia BandettiniNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Marcus Y ChenNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
María J Ledesma-CarbayoBiomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine, Madrid, Spain.
Elliot R McVeighDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA.
University of California, San Diego · USLa Jolla Bioengineering Institute · USUniversidad Politécnica de Madrid · ESNational Heart Lung and Blood Institute · USNational Institutes of Health · US

Funding

Cardiovascular CT Clinical ResearchZIAHL006220 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CHEN, MARCUS · 2017 to 2025
$22.5M
Integrative Bioengineering of Heart, Vessels, and BloodT32HL105373 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, INTAGLIETTA, MARCOS · 2010 to 2019
$3.6M
True 4DCT for Quantifying LV Dyssynchrony and Function for Targeting LV Lead Location in CRTR01HL144678 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCVEIGH, ELLIOT R · 2019 to 2022
$3.3M
Patient-specific thrombosis risk in atrial fibrillation by 4D CT imaging of atrial kinetics combined with computational fluid dynamicsR01HL160024 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEL ALAMO, JUAN CARLOS, KAHN, ANDREW · 2021 to 2024
$2.7M
Comprehensive analysis of endocardial strain using 4DCT dataF31HL151183 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COLVERT, GABRIELLE M. · 2020 to 2021
$55k
Intramural NIH HHS ZIA HL006220NHLBI NIH HHS F31 HL151183NHLBI NIH HHS R01 HL144678NHLBI NIH HHS R01 HL160024NHLBI NIH HHS T32 HL105373NIH HHS 1ZIAHL006220NIH HHS F31HL151183NIH HHS R01HL144678NIH HHS T32HL105373
6 · The paper itself

Abstract

backgroundEstimates of regional left ventricular (LV) strains provide additional information to global function parameters such as ejection fraction (EF) and global longitudinal strain (GLS) and are more sensitive in detecting abnormal regional cardiac function. The accurate and reproducible assessment of regional cardiac function has implications in the management of various cardiac diseases such as heart failure, myocardial ischemia, and dyssynchrony. PURPOSE: To develop a method that yields highly reproducible, high-resolution estimates of regional endocardial strains from 4DCT images.

methodsA method for estimating regional LV endocardial circumferential

resultsThe 4DCT-derived regional strains correlated well with the CMR-derived regional strains (

conclusionsWe have developed a novel method to estimate high-resolution regional LV endocardial circumferential and longitudinal strains from 4DCT images. Except for the definition of the mitral valve and LV outflow tract planes, the method is completely user independent, thus yielding highly reproducible estimates of endocardial strain. The 4DCT-derived strains correlated well with those estimated using a commercial CMR feature tracking software. The promising results reported in this study highlight the potential utility of 4DCT in the precise assessment of regional cardiac function for the management of cardiac disease.

Indexed as

Magnetic Resonance Imaging, CineVentricular Function, LeftHeart VentriclesHumansMagnetic Resonance SpectroscopyReproducibility of Results4DCTcardiac CTLV functionLV myocardial strain

Identifiers

PMID35751864
PMCPMC9474637
OpenAlexW4283452832

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.