Evidence map›Paper›PMID 35751784›Full record

ArticleGenes & genomics2022

Mir-326 potentiates radiosensitivity of cervical squamous cell carcinoma through downregulating SMO expression in the Hedgehog signaling pathway.

Junqin Zhang, Yaxing Li, Yanan Ren, Hua Han, Jie Li

Abstract read
PubMed Publisher
In one paragraph

Article in Genes & genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Junqin ZhangDepartment of Gynecology, Hebei General Hospital, Shijiazhuang, China.
Yaxing LiThe 3rd Department of Oncology, Hebei General Hospital, No. 348 Heping West Road, Xinhua District, Shijiazhuang, 050051, China. zhongsan85988367@126.com.
Yanan RenDepartment of Gynecology, Hebei General Hospital, Shijiazhuang, China.
Hua HanDepartment of Gynecology, Hebei General Hospital, Shijiazhuang, China.
Jie LiDepartment of Gynecology, Hebei General Hospital, Shijiazhuang, China.
Hebei General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiotherapy resistance affects the therapeutic effect of cervical squamous cell carcinoma (CSCC). Smoothened (Smo) is an anticancer target of the Hedgehog (Hh) pathway and its mutation is related to drug resistance.

objectiveTo explore the roles of miR-326 and Smoothened (SMO) on radiation resistance in patients with cervical carcinoma.

methodsExpression of miR-326 and SMO in cervical cancer tissue and radioresistant cell lines were analyzed. The radiation response with the expression of miR-326 was evaluated in tissue and cells. Bioinformatics analysis and literature review were performed to explore the target of miR-326. The regulation of miR-326 to SMO mRNA was verified through the dual-luciferase reporter assay.

resultsPatients with poor radiation response have lower miR-326 and higher SMO expression. Upregulation of miR-326 decreased SMO expression and its downstream proteins but does not affect the proliferation of CSCC cells. The upregulation of miR-326 increased radiation sensitivity of the CSCC cell through downregulating SMO and its downstream proteins in the Hedgehog (Hh) signaling pathway.

conclusionsmiR-326 may predict the treatment response to radiation, and upregulating miR-326 may improve the treatment response to radiation.

Indexed as

Carcinoma, Squamous CellMicroRNAsUterine Cervical NeoplasmsFemaleHedgehog ProteinsHumansRadiation ToleranceSignal TransductionSmoothened ReceptorHedgehog ProteinsMicroRNAsMIRN326 microRNA, humanSmoothened ReceptorSMO protein, humanCervical squamous cell carcinomaHedgehog pathwaymiR-326Radiation resistanceSmoothened (SMO)

Identifiers

PMID35751784
OpenAlexW4283516585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.