Evidence map›Paper›PMID 35751782›Full record

ArticleVeterinary research communications2023

In vitro and in vivo evaluation of kinase and protease inhibitors against Trypanosoma evansi.

Wangchuk Dorjee Bhutia, Snehil Gupta, Ruma Rani, Kanisht Batra, Khushboo Sethi, Sanjay Kumar, Rajender Kumar

Abstract read
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In one paragraph

Article in Veterinary research communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wangchuk Dorjee BhutiaParasitology Lab, ICAR-National Research Centre on Equines, Hisar, Haryana, 125001, India.
Snehil GuptaDepartment of Veterinary Parasitology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, 125001, India.
Ruma RaniParasitology Lab, ICAR-National Research Centre on Equines, Hisar, Haryana, 125001, India.
Kanisht BatraDepartment of Animal Biotechnology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, 125001, India.
Khushboo SethiParasitology Lab, ICAR-National Research Centre on Equines, Hisar, Haryana, 125001, India.
Sanjay KumarParasitology Lab, ICAR-National Research Centre on Equines, Hisar, Haryana, 125001, India.
Rajender KumarParasitology Lab, ICAR-National Research Centre on Equines, Hisar, Haryana, 125001, India. rkg.nrce@gmail.com.ORCID http://orcid.org/0000-0002-2958-2193
National Research Centre on Equines · INLala Lajpat Rai University of Veterinary and Animal Sciences · IN

Funding

Indian Council of Agriculture Research F. No. F No. 3(1)/2020-Budget- NRCE sub-scheme
6 · The paper itself

Abstract

Trypanosoma evansi is a causative agent of chronic wasting and fatal disease of livestock and wild animals known as surra. In this study, repurposing approach based on drug target was used to investigate the efficacy of kinase inhibitors (Barasertib-HQPA, BAR and Palbociclib isethionate, PAL) and protease inhibitors (Z-pro-prolinal, Z-PRO and Leupeptin hemisulphate, LEU) against T. evansi in HMI-9 medium. BAR, PAL and Z-PRO exhibited IC

Indexed as

Protease InhibitorsTrypanosomaAnimalsAnimals, WildAurora KinasesHorsesLeukocytes, MononuclearMiceAurora KinasesProtease InhibitorsIndiaKinase inhibitorsProtease inhibitorsSurraTrypanosoma evansi

Identifiers

PMID35751782
OpenAlexW4283455581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.