Evidence map›Paper›PMID 35751700›Full record

ArticleActa neurochirurgica2022

Subthalamic nucleus deep brain stimulation programming settings do not correlate with Parkinson's disease severity.

Rena Far, Ignacio Saez, Angela Sardo, Eric Royz, Laura Sperry, Lin Zhang, Kiarash Shahlaie, Fady Girgis

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Article in Acta neurochirurgica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Rena FarDepartment of Clinical Neurosciences, University of Calgary, 1403 29 Street NW, Calgary, AB, T2N 2T9, Canada. rena.far@ucalgary.ca.ORCID http://orcid.org/0000-0002-7821-3132
Ignacio SaezDepartment of Neurological Surgery, University of California Davis, Sacramento, CA, USA.
Angela SardoSchool of Medicine, University of California Davis, Sacramento, CA, USA.
Eric RoyzSchool of Medicine, University of California Davis, Sacramento, CA, USA.
Laura SperryDepartment of Neurology, University of California Davis, Sacramento, CA, USA.
Lin ZhangDepartment of Neurology, University of California Davis, Sacramento, CA, USA.
Kiarash ShahlaieDepartment of Neurological Surgery, University of California Davis, Sacramento, CA, USA.
Fady GirgisDepartment of Clinical Neurosciences, University of Calgary, 1403 29 Street NW, Calgary, AB, T2N 2T9, Canada.
University of California, Davis · USNeurological Surgery · USUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDeep brain stimulation (DBS) is a well-established treatment for Parkinson's disease (PD). While the success of DBS is dependent on careful patient selection and accurate lead placement, programming parameters play a pivotal role in tailoring therapy on the individual level. Various algorithms have been developed to streamline the initial programming process, but the relationship between pre-operative patient characteristics and post-operative device settings is unclear. In this study, we investigated how PD severity correlates with DBS settings.

methodsWe conducted a retrospective review of PD patients who underwent DBS of the subthalamic nucleus at one US tertiary care center between 2014 and 2018. Pre-operative patient characteristics and post-operative programming data at various intervals were collected. Disease severity was measured using the Unified Parkinson's Disease Rating Scale score (UPDRS) as well as levodopa equivalent dose (LED). Correlation analyses were conducted looking for associations between pre-operative disease severity and post-operative programming parameters.

resultsFifty-six patients were analyzed. There was no correlation between disease severity and any of the corresponding programming parameters. Pre-operative UPDRS scores on medication were similar to post-operative scores with DBS. Settings of amplitude, frequency, and pulse width increased significantly from 1 to 6 months post-operatively. Stimulation volume, inferred by the distance between contacts used, also increased significantly over time.

conclusionsInterestingly, we found that patients with more advanced disease responded to electrical stimulation similarly to patients with less advanced disease. These data provide foundational knowledge of DBS programming parameters used in a single cohort of PD patients over time.

Indexed as

Deep Brain StimulationParkinson DiseaseSubthalamic NucleusHumansLevodopaSeverity of Illness IndexTreatment OutcomeLevodopaDeep brain stimulationDyskinesiasElectric stimulationElectrodesImplantedParkinson’s diseaseSubthalamic nucleus

Identifiers

PMID35751700
OpenAlexW4283523736

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.