Evidence map›Paper›PMID 35751660›Full record

ReviewLung2022

Quantitative Computed Tomography: What Clinical Questions Can it Answer in Chronic Lung Disease?

Marcelo Cardoso Barros, Stephan Altmayer, Alysson Roncally Carvalho, Rosana Rodrigues, Matheus Zanon, Tan-Lucien Mohammed, Pratik Patel, Al-Ani Mohammad, Borna Mehrad, Jose Miguel Chatkin and 1 more

Abstract readReview
In one paragraph

Review in Lung, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Quantitative computed tomography and predictive modelling for COPD exacerbations.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marcelo Cardoso BarrosPontificia Universidade Catolica do Rio Grande do Sul, Av. Ipiranga, 6681, Porto Alegre - RS, 90619-900, Brazil. macardosob@gmail.com.
Stephan AltmayerDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
Alysson Roncally CarvalhoDepartment of Radiology, Instituto Dor, Rio de Janeiro, Brazil.
Rosana RodriguesDepartment of Radiology, Instituto Dor, Rio de Janeiro, Brazil.
Matheus ZanonPontificia Universidade Catolica do Rio Grande do Sul, Av. Ipiranga, 6681, Porto Alegre - RS, 90619-900, Brazil.
Tan-Lucien MohammedDepartment of Radiology, University of Florida, Gainesville, FL, USA.
Pratik PatelDepartment of Radiology, University of Florida, Gainesville, FL, USA.
Al-Ani MohammadDepartment of Medicine, University of Florida, Gainesville, FL, USA.
Borna MehradDepartment of Medicine, University of Florida, Gainesville, FL, USA.
Jose Miguel ChatkinPontificia Universidade Catolica do Rio Grande do Sul, Av. Ipiranga, 6681, Porto Alegre - RS, 90619-900, Brazil.
Bruno HochheggerDepartment of Radiology, University of Florida, Gainesville, FL, USA.

Funding

Together: Transforming and Translating Discovery to Improve HealthKL2TR001429 · NCATS · UNIVERSITY OF FLORIDA · PI GUIRGIS, FAHEEM W, LEEUWENBURGH, CHRISTIAAN · 2015 to 2023
$5.5M
Multiscale modeling of the role of heme during invasive pulmonary aspergillosisR01AI135128 · NIAID · UNIVERSITY OF FLORIDA · PI REINHARD LAUBENBACHER, Borna Mehrad · 2018 to 2026
$4.9M
Modular design of multiscale models, with an application to the innate immune response to fungal respiratory pathogens.U01EB024501 · NIBIB · UNIVERSITY OF FLORIDA · PI LAUBENBACHER, REINHARD, MEHRAD, BORNA · 2017 to 2020
$2.9M
NCATS NIH HHS KL2 TR001429NIAID NIH HHS R01 AI135128NIBIB NIH HHS U01 EB024501
6 · The paper itself

Abstract

Quantitative computed tomography (QCT) has recently gained an important role in the functional assessment of chronic lung disease. Its capacity in diagnostic, staging, and prognostic evaluation in this setting is similar to that of traditional pulmonary function testing. Furthermore, it can demonstrate lung injury before the alteration of pulmonary function test parameters, and it enables the classification of disease phenotypes, contributing to the customization of therapy and performance of comparative studies without the intra- and inter-observer variation that occurs with qualitative analysis. In this review, we address technical issues with QCT analysis and demonstrate the ability of this modality to answer clinical questions encountered in daily practice in the management of patients with chronic lung disease.

Indexed as

LungLung DiseasesHumansObserver VariationRespiratory Function TestsTomography, X-Ray ComputedChronic lung diseaseFunctional CTQuantitative CT

Identifiers

PMID35751660
PMCPMC9378468

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.