ArticlePlant physiology2022
A calmodulin-like protein (CML10) interacts with cytosolic enzymes GSTU8 and FBA6 to regulate cold tolerance.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Tropical vulnerability and temperate resilience: molecular and physiological insights into cold stress adaptation in oil palm.GM crops & food · 2026Review
- The glutathione S-transferase gene LaGSTU6 promotes somatic embryogenesis in a recalcitrant lily genotype by regulating scales redox homeostasis.Molecular horticulture · 2026Article
- Dynamic and non-additive gene regulation shapes maize responses to simultaneous salt and cold stress.Functional & integrative genomics · 2026Article
- The SlARF6A-SlFBA3/SlSGR Module Regulates the Resistance of Tomatoes to Pseudomonas syringae pv. tomato.Molecular plant pathology · 2026Article
- A rice calmodulin-like protein OsCML27 participates in drought tolerance by fine-tuning OsRbohB-mediated ROS signaling.Science advances · 2026Article
- Genome-Wide Identification and Expression Analysis of theCurrent issues in molecular biology · 2026Article
- A Salt-ResponsiveInternational journal of molecular sciences · 2026Article
- Calmodulin-Like Protein MfCML50 Interacts With Carveol Dehydrogenase in Medicago falcata to Regulate Cold Tolerance Through Mediating ROS Homeostasis.Plant biotechnology journal · 2026Article
- PpCML14 from Kentucky bluegrass confers drought and salinity tolerance in transgenic rice.Plant cell reports · 2026Article
- ZmmiR1432-ZmCML21-ZmPMA2 Module Affects Maize Low Phosphate Tolerance via Regulating Organic Acid Secretion.Plant biotechnology journal · 2026Article
- O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering.Nature communications · 2025Article
- The CtrCBL1/CtrCIPK6 Complex of Citrus Phosphorylates CtrBBX32 to Regulate CtrSTP1-Mediated Sugar Accumulation and Cold Tolerance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mechanistic Insights into the Abiotic Stress Adaptation ofCurrent issues in molecular biology · 2025Review
- Effects of Combined Salt and Heat Stress on Agronomic Traits, Photosynthetic Parameters, and Physiological Biochemistry in Six Alfalfa (Plants (Basel, Switzerland) · 2025Article
- Forage Crop Research in the Modern Age.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Genome-Wide Analysis of theInternational journal of molecular sciences · 2025Article
- Genome-Wide Characterization ofInternational journal of molecular sciences · 2025Article
- Transcriptome Analysis of thePlants (Basel, Switzerland) · 2025Article
- Molecular Mechanisms of Alfalfa Response to Abiotic Stresses.Plants (Basel, Switzerland) · 2025Review
- A MaizeInternational journal of molecular sciences · 2025Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
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Abstract
Calmodulin-like proteins (CMLs) are calcium (Ca2+) sensors involved in plant growth and development as well as adaptation to environmental stresses; however, their roles in plant responses to cold are not well understood. To reveal the role of MsCML10 from alfalfa (Medicago sativa) in regulating cold tolerance, we examined transgenic alfalfa and Medicago truncatula overexpressing MsCML10, MsCML10-RNAi alfalfa, and a M. truncatula cml10-1 mutant and identified MsCML10-interacting proteins. MsCML10 and MtCML10 transcripts were induced by cold treatment. Upregulation or downregulation of MsCML10 resulted in increased or decreased cold tolerance, respectively, while cml10-1 showed decreased cold tolerance that was complemented by expressing MsCML10, suggesting that MsCML10 regulates cold tolerance. MsCML10 interacted with glutathione S-transferase (MsGSTU8) and fructose 1,6-biphosphate aldolase (MsFBA6), and the interaction depended on the presence of Ca2+. The altered activities of Glutathione S-transferase and FBA and levels of ROS and sugars were associated with MsCML10 transcript levels. We propose that MsCML10 decodes the cold-induced Ca2+ signal and regulates cold tolerance through activating MsGSTU8 and MsFBA6, leading to improved maintenance of ROS homeostasis and increased accumulation of sugars for osmoregulation, respectively.
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