Evidence map›Paper›PMID 35751396›Full record

ReviewEmerging microbes & infections2022

Monkeypox virus emerges from the shadow of its more infamous cousin: family biology matters.

Yan Xiang, Addison White

Open access · goldAbstract readReview
In one paragraph

Review in Emerging microbes & infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 188 citations in OpenAlex.

  1. A comprehensive overview of monkeypox virus disease.Tropical medicine and health · 2026
    Review
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  18. Viral genomic features predictbioRxiv : the preprint server for biology · 2024
    Article
  19. Review
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yan XiangDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center, San Antonio, TX, USA.
Addison WhiteDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center, San Antonio, TX, USA.
The University of Texas Health Science Center at San Antonio · US

Funding

Novel Translational Control Mechanisms in Host Range Restriction of PoxvirusR01AI151638 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI YAN XIANG · 2020 to 2026
$3.4M
Developing small molecule inhibitors for modulating cytokine IL18 activitiesR21AI153948 · NIAID · OKLAHOMA STATE UNIVERSITY STILLWATER · PI DENG, JUNPENG · 2021 to 2022
$430k
Structure function studies of a molecular complex for generating viral membraneR21AI149295 · NIAID · OKLAHOMA STATE UNIVERSITY STILLWATER · PI DENG, JUNPENG, XIANG, YAN · 2020 to 2021
$430k
NIAID NIH HHS R01 AI151638NIAID NIH HHS R21 AI149295NIAID NIH HHS R21 AI153948
6 · The paper itself

Abstract

Monkeypox virus (MPXV) is closely related to the infamous variola (smallpox) virus, causing a febrile rash illness in humans similar to but milder than smallpox. In the twentieth century, human monkeypox had been mostly a rare zoonotic disease confined to forested areas in West and Central Africa. However, the case number and geographic range have increased significantly in this century, coincided with the waning of the smallpox vaccine-induced immunity in the global population. The outbreak of human monkeypox in multiple countries since May 2022 has been unusual in its large case number and the absence of direct links to endemic countries, raising concerns for a possible change in monkeypox transmission pattern that could pose a greater global threat. Here, we review aspects of MPXV biology that are relevant for risk assessment and preparedness for a monkeypox epidemic, with an emphasis on recent progress in understanding of the virus host range, evolutionary potential, and neutralization targets.

Indexed as

Mpox, MonkeypoxSmallpoxBiologyDisease OutbreaksHumansMonkeypox virusantibodiesevolutionhost rangemonkeypoxPoxvirus

Identifiers

PMID35751396
PMCPMC9278444
OpenAlexW4283520008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.