ArticleAdvanced healthcare materials2022
Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields.
Article in Advanced healthcare materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advances in the application of temporal interference stimulation: a scoping review.Frontiers in human neuroscience · 2025Pooled it
- Personalized high-intensity temporal interference stimulation decouples cerebellar networks to enhance implicit learning.Journal of neuroengineering and rehabilitation · 2026Trial
- Neuroimmune Dynamics in Diseases of the Arterial Wall: Mechanistic Foundations and Translational Prospects.Current atherosclerosis reports · 2026Review
- Temporal Interference Electrical Stimulation for Neuropsychiatric Disorders: Mechanisms, Applications, and Translational Perspectives.International journal of molecular sciences · 2026Review
- Transcutaneous interference spinal cord stimulation: leadfield-based pareto optimization of electrode montages for improved focality.Biomedical engineering letters · 2026Article
- Frequency shaping of tactile perception via transcutaneous interferential electrical stimulation: a simulation study.Frontiers in neuroscience · 2026Article
- Temporal interference stimulation of peripheral nerves induces functionally diverse limb movements revealed by automated pose estimation and unsupervised behavioral analysis.Journal of neuroengineering and rehabilitation · 2025Article
- Review
- The same biophysical mechanism is involved in both temporal interference and direct kHz stimulation of peripheral nerves.Nature communications · 2025Article
- Non-invasive Modulation of Deep Brain Nuclei by Temporal Interference Stimulation.Neuroscience bulletin · 2025Article
- Focal control of non-invasive deep brain stimulation using multipolar temporal interference.Bioelectronic medicine · 2025Article
- Research progress in different physical therapies for treating peripheral nerve injuries.Frontiers in neurology · 2025Review
- Advances in piezoelectric nanogenerators for self-powered cardiac care.Nano trends (2023) · 2024Article
- Quantitative analysis of noninvasive deep temporal interference stimulation: A simulation and experimental study.Heliyon · 2024Article
- Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound.Nature communications · 2024Article
- Interfering with sleep apnea.Bioelectronic medicine · 2024Article
- Why Temporal Inference Stimulation May Fail in the Human Brain: A Pilot Research Study.Biomedicines · 2023Article
- A novel non-invasive brain stimulation technique: "Temporally interfering electrical stimulation".Frontiers in neuroscience · 2023Review
- Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields.Advanced healthcare materials · 2022Article
- Transcranial Electrical Neurostimulation as a Potential Addiction Treatment.Inquiry : a journal of medical care organization, provision and financingReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrical stimulation of peripheral nerves is a cornerstone of bioelectronic medicine. Effective ways to accomplish peripheral nerve stimulation (PNS) noninvasively without surgically implanted devices are enabling for fundamental research and clinical translation. Here, it is demonstrated how relatively high-frequency sine-wave carriers (3 kHz) emitted by two pairs of cutaneous electrodes can temporally interfere at deep peripheral nerve targets. The effective stimulation frequency is equal to the offset frequency (0.5 - 4 Hz) between the two carriers. This principle of temporal interference nerve stimulation (TINS) in vivo using the murine sciatic nerve model is validated. Effective actuation is delivered at significantly lower current amplitudes than standard transcutaneous electrical stimulation. Further, how flexible and conformable on-skin multielectrode arrays can facilitate precise alignment of TINS onto a nerve is demonstrated. This method is simple, relying on the repurposing of existing clinically-approved hardware. TINS opens the possibility of precise noninvasive stimulation with depth and efficiency previously impossible with transcutaneous techniques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.