E2

Sana Zahid, Mehreen Gul, Shagufta Shafique, Sajid Rashid

Open access · greenAbstract read

In one paragraph

Article in Computers in biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.3field-weighted citation impact, top 49% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sana ZahidNational Center for Bioinformatics, Quaid-i-Azam University, Islamabad, 42000, Pakistan.

Mehreen GulNational Center for Bioinformatics, Quaid-i-Azam University, Islamabad, 42000, Pakistan.

Shagufta ShafiqueNational Center for Bioinformatics, Quaid-i-Azam University, Islamabad, 42000, Pakistan.

Sajid RashidNational Center for Bioinformatics, Quaid-i-Azam University, Islamabad, 42000, Pakistan. Electronic address: sajid@qau.edu.pk.

Quaid-i-Azam University · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homologous to E6AP carboxyl-terminus (HECT)-type E3 ligase performs ubiquitin (Ub)-proteasomal protein degradation via forming a complex with E2∼Ub. Enveloped viruses including SARS-CoV-2 escape from the infected cells by harnessing the E-class vacuolar protein-sorting (ESCRT) machinery and mimic the cellular system through PPAY motif-based linking to HECT Ub ligase activity. In the present study, we have characterized the binding pattern of E2

Indexed as

COVID-19UbiquitinBinding SitesEndosomal Sorting Complexes Required for TransportHumansLigandsNerve Tissue ProteinsPeptidesProtein BindingSARS-CoV-2Ubiquitin-Protein LigasesEndosomal Sorting Complexes Required for TransportHECW1 protein, humanHECW2 protein, humanLigandsNerve Tissue ProteinsPeptidesUbiquitinUbiquitin-Protein LigasesWWP1 protein, humanWWP2 protein, humanMolecular dynamicsPeptide-driven blockageSARS-CoV-2Viral egression

Identifiers

PMID35751189

DOI10.1016/j.compbiomed.2022.105660

PMCPMC9124161

OpenAlexW4281264578

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.