ArticlePediatric obesity2022
Association between maternal antibiotic exposure during pregnancy and childhood obesity in the Japan Environment and Children's Study.
Article in Pediatric obesity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Risk Factors in the First 1000 Days of Life Associated With Childhood Obesity: A Systematic Review and Risk Factor Quality Assessment.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- The association between prenatal and early-life antibiotic use and obesity at 4-5 years in the Born in Bradford birth cohort.BMC public health · 2026Article
- Early-life antibiotic exposure and the risk of overweight and obesity in children.Pediatric research · 2026Article
- Antibiotic Exposure and Childhood Overweight/Obesity: Evidence from Epidemiological and Experimental Studies.Current pharmaceutical design · 2025Review
- Association between maternal antibiotic exposure during pregnancy and childhood obesity in the Japan Environment and Children's Study.Pediatric obesity · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between maternal antibiotic exposure during pregnancy and childhood obesity is still unclear.
objectivesThe study aimed to evaluate the association between prenatal exposure to antibiotics and obesity at age 3 years using data from a large Japanese birth cohort.
methodsThe Japan Environment and Children's Study is a nationwide birth cohort study. In this study, singleton vaginal full-term births were included. Obesity was defined as body mass index ≥95th percentile according to child growth standards. Prenatal antibiotic exposure was defined as antimicrobial agent use during pregnancy and was collected from maternal interviews and medical record transcripts. Logistic regression analysis was performed to evaluate the association of prenatal antibiotic exposure with child obesity at 3 years.
resultsIn the crude and adjusted models with all children, maternal antibiotic exposure during pregnancy showed a marginal relationship with child obesity at 3 years. In the analyses according to exposure period and sex, exposure to antibiotics during the second/third trimester was significantly associated with obesity at the age of 3 years in female infants, but not in male infants, although the exposure during the first trimester was not in both sexes.
conclusionMaternal antibiotic exposure during mid/late pregnancy may result in child obesity.
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