Evidence map›Paper›PMID 35751058›Full record

ArticleMolecular cancer2022

Optimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge.

Junfeng Jiang, Tao Zeng, Li Zhang, Xingfei Fan, Qishu Jin, Haitao Ni, Yusheng Ye, Lipeng Cheng, Li Li, Liujun Wang and 15 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Junfeng Jiang *Histology and Embryology Department, Naval Medical University, Shanghai, 200433, China.ORCID 0000-0003-2696-2032
Tao Zeng *Histology and Embryology Department, Naval Medical University, Shanghai, 200433, China.
Li Zhang *Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai, 200433, China.
Xingfei Fan *Histology and Embryology Department, Naval Medical University, Shanghai, 200433, China.
Qishu JinDepartment of Histology and Embryology, Harbin Medical University, Harbin, 150086, China.
Haitao NiHistology and Embryology Department, Naval Medical University, Shanghai, 200433, China.
Yusheng YeHistology and Embryology Department, Naval Medical University, Shanghai, 200433, China.
Lipeng ChengHistology and Embryology Department, Naval Medical University, Shanghai, 200433, China.
Li LiHistology and Embryology Department, Naval Medical University, Shanghai, 200433, China.
Liujun WangHistology and Embryology Department, Naval Medical University, Shanghai, 200433, China.
Sha XuHistology and Embryology Department, Naval Medical University, Shanghai, 200433, China.
Yu YangHistology and Embryology Department, Naval Medical University, Shanghai, 200433, China.
Juan GuHistology and Embryology Department, Naval Medical University, Shanghai, 200433, China.
Bing GuoDepartment of Oral & Maxillofacial - Head & Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Lei WangDepartment of Oral & Maxillofacial - Head & Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Xin LiDepartment of Oral & Maxillofacial - Head & Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Yingyi QinDepartment of health statistics, Naval Medical University, Shanghai, 200433, China.
Jiaxi LiDepartment of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Jinjiang WangDepartment of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Xi ChenDepartment of Cell and Neurobiology, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, Los Angeles, California, 90033, USA.
Minjuan WuHistology and Embryology Department, Naval Medical University, Shanghai, 200433, China.
Qi-Long YingDepartment of Cell and Neurobiology, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, Los Angeles, California, 90033, USA. qying@med.usc.edu.
Xingjun QinDepartment of Oral & Maxillofacial - Head & Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. qinxj1989@sina.com.
Yefei WangDepartment of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. paper34@163.com.
Yue WangHistology and Embryology Department, Naval Medical University, Shanghai, 200433, China. wangyuesmmu@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MicroRNAsBase SequenceCRISPR-Cas SystemsGene EditingHeLa CellsHumansMicroRNAsCRISPR–Cas9Let-7miRNA spongeRNA sequence optimization

Identifiers

PMID35751058
PMCPMC9229757

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.