ArticleBMC pregnancy and childbirth2022
The trend in delayed childbearing and its potential consequences on pregnancy outcomes: a single center 9-years retrospective cohort study in Hubei, China.
Article in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Maternal age 30-34 years and adverse perinatal outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Pooled it
- Influence of Varicocelectomy on Assisted Reproductive Technology Outcomes of Infertile Patients with Varicocele: A Systematic Review and Meta-Analysis.American journal of men's healthPooled it
- The impact of advanced maternal age on the risk of perineal and anal sphincter injuries in nulliparous women.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Ginsenoside Re Attenuates D-Galactose-Induced Aging-like Oxidative Stress in Cultured Bovine Oocytes via Activation of the SIRT1/Nrf2 Signaling Pathway.International journal of molecular sciences · 2026Article
- Potential for primary prevention of low birth weight in pregnancies with and without gestational diabetes mellitus: a prospective cohort study in Central China.BMC pregnancy and childbirth · 2026Article
- Adverse Pregnancy Outcomes and Long-Term Risk of Chronic Diseases: Evidence from the Findings of the Tehran Lipid and Glucose Study During a Quarter of a Century.International journal of endocrinology and metabolism · 2026Review
- Protocol for a multicentre survey of sexual and reproductive health and fertility among unmarried women living in China's megacities.BMJ open · 2026Article
- Comparison status and factors of pregnancy stress among pregnant women with second child between advanced maternal age and reproductive age: a cross-sectional study.BMC pregnancy and childbirth · 2026Article
- The socio-environmental exposome and maternal cardiometabolic health in the us: a machine learning approach.American journal of preventive cardiology · 2026Article
- Effects of Supervised Physiotherapy-Based Exercise on Ovarian Reserve and Spontaneous Pregnancy in Women with Diminished Ovarian Reserve: A Controlled Pilot Study.Life (Basel, Switzerland) · 2026Article
- Modeled Burden and Trends of Infertility Among People Aged 15-49 Years in the Original BRICS Countries: Comparisons with G7 and Global Estimates, 1990-2023, with Projections to 2050.International journal of women's health · 2026Article
- Temporal trend and influencing factors of high-risk pregnancy in China: a nationwide longitudinal analysis.Frontiers in public health · 2026Article
- Article
- Assessment of the Burden of Maternal Hypertensive Disorders and the Quality of Care in China: A Systematic Analysis of the Global Burden of Disease (GBD) 2021 Study.International journal of women's health · 2026Article
- Postponed childbearing: a cross-sectional study of differences between subjective and objective factors.Annals of medicine · 2025Article
- Abnormal cholesterol-cholesteryl ester metabolism impairs mouse oocyte quality during ovarian aging.Cellular & molecular biology letters · 2025Article
- Exploring the shifting landscape of delayed motherhood in India: a comprehensive analysis using joinpoint and age-period-cohort analysis.BMC women's health · 2025Article
- The mediating role of the intimate relationship between dyadic coping and reproductive concerns in breast cancer patients of childbearing age: a descriptive cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- The optimal childbearing age and birth spacing in china: a multicenter retrospective cohort study.BMC public health · 2025Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to the advancement of modern societies, the proportion of women who delay childbearing until or beyond 30 years has dramatically increased in the last three decades and has been linked with adverse maternal-neonatal outcomes.
objectiveTo determine the trend in delayed childbearing and its negative impact on pregnancy outcomes. MATERIAL AND
methodsA tertiary hospital-based retrospective study was conducted in Wuhan University Renmin Hospital, Hubei Province, China, during the years 2011-2019. The joinpoint regression analysis was used to find a trend in the delayed childbearing and the multiple binary logistic regression model was used to estimate the association between maternal age and pregnancy outcomes.
resultsBetween 2011 and 2019, the trend in advanced maternal age (AMA ≥35 years) increased by 75% [AAPC 7.5% (95% CI: - 10.3, 28.9)]. Based on maternal education and occupation, trend in AMA increased by 130% [AAPC 11.8% (95% CI: 1.1, 23.7)] in women of higher education level, and 112.5% [AAPC 10.1% (95% CI: 9.4, 10.9)] in women of professional services. After adjusting for confounding factors, AMA was significantly associated with increased risk of gestational hypertension (aOR 1.5; 95% CI: 1.2, 2.1), preeclampsia (aOR 1.6; 95% CI: 1.4, 1.9), sever preeclampsia (aOR 1.7; 95% CI: 1.1, 2.6), placenta previa (aOR 1.8; 95% CI: 1.5, 2.2), gestational diabetes mellitus (aOR 2.5; 95% CI: 2.3, 2.9), preterm births (aOR 1.6; 95% CI: 1.4, 1.7), perinatal mortality (aOR 1.8; 95% CI: 1.3, 2.3), and low birth weight (aOR 1.3; 95% CI: 1.2, 1.4) compared with women aged < 30 years.
conclusionOur findings show a marked increase in delayed childbearing and its negative association with pregnancy outcomes.
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