Evidence map›Paper›PMID 35750926›Full record

ArticleSleep & breathing = Schlaf & Atmung2023

Continuous positive airway pressure treatment of obstructive sleep apnea and hypertensive complications in high-risk pregnancy.

Alexandra Lauren Rice, Sakshi Bajaj, Abigail M Wiedmer, Natalie Jacobson, Aleksandar K Stanic, Kathleen M Antony, Mihaela H Bazalakova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandra Lauren RiceDepartment of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 1010 Mound Street, Madison, WI, USA.
Sakshi BajajDepartment of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 1010 Mound Street, Madison, WI, USA.
Abigail M WiedmerDepartment of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 1010 Mound Street, Madison, WI, USA.
Natalie JacobsonDepartment of Biology, University of Wisconsin-Madison, Madison, WI, USA.
Aleksandar K StanicDepartment of Obstetrics and Gynecology, Division of Reproductive Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Kathleen M AntonyDepartment of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 1010 Mound Street, Madison, WI, USA.
Mihaela H BazalakovaDepartment of Neurology, Wisconsin Sleep, Wisconsin Institute for Sleep and Consciousness, School of Medicine and Public Health, University of Wisconsin-Madison, 1685 Highland Ave, Madison, WI, 53705, USA. bazalakova@wisc.edu.ORCID 0000-0002-1718-3320

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
NCATS NIH HHS UL1 TR002373
6 · The paper itself

Abstract

purposeTo evaluate whether or not continuous positive airway pressure (CPAP) treatment in pregnancies complicated by obstructive sleep apnea (OSA) is associated with a decrease in hypertensive disorders of pregnancy.

methodsThis was a retrospective cohort study of perinatal outcomes in women who underwent objective OSA testing and treatment as part of routine clinical care during pregnancy. Where diagnostic criteria for OSA were reached (respiratory event index (REI) ≥ 5 events per hour), patients were offered CPAP therapy. Obstetrical outcomes were compared between the control group (no OSA), the group with untreated OSA (OSA diagnosed, not CPAP compliant), and the group with treated OSA (OSA diagnosed and CPAP compliant), with CPAP compliance defined as CPAP use ≥ 4 h, 70% of the time or greater. A composite hypertension outcome combined diagnoses of gestational hypertension (gHTN) and preeclampsia (PreE) of any severity.

resultsThe study comprised outcomes from 177 completed pregnancies. Our cohort was characterized by obesity, with average body mass indices > 35 kg/m

conclusionReal-world data in this small study suggest that CPAP therapy may modulate the increased risk of hypertensive complications in pregnancies complicated by OSA.

Indexed as

HypertensionSleep Apnea, ObstructiveAdultContinuous Positive Airway PressureFemaleHumansInfantPregnancyPregnancy, High-RiskRetrospective StudiesContinuous positive airway pressureGestational hypertensionObesityPreeclampsiaPregnancySleep apnea

Identifiers

PMID35750926
PMCPMC9789204

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.