ArticleScientific reports2022
Associations of body shape phenotypes with sex steroids and their binding proteins in the UK Biobank cohort.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Associations of leucocyte subtypes and platelet parameters with kidney cancer risk in the UK Biobank cohort.Journal of inflammation (London, England) · 2025Article
- Beyond BMI: A Mendelian Randomization Study of the Causal Effects and Mediating Pathways of Regional Adipose Tissue Depots on Polycystic Ovary Syndrome.International journal of women's health · 2025Article
- Sex disparity in the association between metabolic-anthropometric phenotypes and risk of obesity-related cancer: a prospective cohort study.BMC medicine · 2024Article
- Prospective associations of leucocyte subtypes and obesity with the risk of developing cutaneous malignant melanoma in the UK Biobank cohort.BMC cancer · 2024Article
- Links between the genetic determinants of morning plasma cortisol and body shape: a two-sample Mendelian randomisation study.Scientific reports · 2024Article
- Interactions of obesity, body shape, diabetes and sex steroids with respect to prostate cancer risk in the UK Biobank cohort.Cancer medicine · 2024Article
- Interactions of platelets with obesity in relation to lung cancer risk in the UK Biobank cohort.Respiratory research · 2023Article
- Associations of obesity and body shape with erythrocyte and reticulocyte parameters in the UK Biobank cohort.BMC endocrine disorders · 2023Article
- A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort.BMC cancer · 2023Article
- Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer?Journal of clinical medicine · 2023Review
- Sex differences in the associations of body size and body shape with platelets in the UK Biobank cohort.Biology of sex differences · 2023Article
- Diet Composition, Anthropometrics, and Mortality Risk.International journal of environmental research and public health · 2022Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Associations of sex steroids and their binding proteins with body shape are unclear, because waist and hip circumference are correlated strongly with body size. We defined body shape using "a body shape index" (ABSI) and hip index (HI), which are independent of weight and height by design, and examined associations in multivariable generalised linear models for the UK Biobank cohort (179,902 men, 207,444 women). Total testosterone was associated inversely with ABSI, especially in men. Free testosterone was lowest for large-ABSI-large-HI ("wide") and highest for small-ABSI-small-HI ("slim") in men, but lowest for small-ABSI-large-HI ("pear") and highest for large-ABSI-small-HI ("apple") in women. Oestradiol was associated inversely with ABSI in obese pre-menopausal women but positively with HI in obese men and post-menopausal women not using hormone replacement therapy. Sex-hormone binding globulin (SHBG) was associated inversely with ABSI but positively with HI and was lowest for "apple" and highest for "pear" phenotype in both sexes. Albumin was associated inversely with HI in women, but matched the pattern of free testosterone in obese men (lowest for "wide", highest for "slim" phenotype). In conclusion, sex steroids and their binding proteins are associated with body shape, including hip as well as waist size, independent of body size.
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