ArticleMolecular psychiatry2022
Shared genetic basis between reproductive behaviors and anxiety-related disorders.
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Genetic insights into the relationship between age at menarche and mental health-related phenotypes.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Genetic predispositions for anxiety disorders and major depressive disorder affect current dietary habits in older patients with lifestyle-related diseases.The international journal of neuropsychopharmacology · 2026Article
- Genetic Association of Sexual Behavior, Sildenafil, and Hormonal Contraceptives With Mental Disorders.CNS neuroscience & therapeutics · 2026Article
- OPRM1 gene polymorphism linked to anxiety in cancer-related pain patients: an observational study.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Association of female reproductive traits with altered aging trajectories: Insights from genetic and observational analyses.Cell reports. Medicine · 2025Observational
- Influences of genetic factors for educational attainment and cognitive functions on current dietary consumption.iScience · 2025Article
- Clinical features and genetic mechanisms of anxiety, fear, and avoidance: A comprehensive review of five anxiety disorders.Molecular psychiatry · 2025Review
- Sexuality and Related Disorders in OCD and Their Symptoms.Journal of clinical medicine · 2025Review
- Regression and machine learning approaches identify potential risk factors for glioblastoma multiforme.Brain communications · 2025Article
- Neuroticism and posttraumatic stress disorder: A Mendelian randomization analysis.Brain and behavior · 2024Article
- Causal associations between female reproductive behaviors and psychiatric disorders: a lifecourse Mendelian randomization study.BMC psychiatry · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Reproductive behaviors are associated with risks for psychiatric disorders. Reproductive phenotypes are moderately heritable and have genetic overlaps with risks for psychiatric disorders. However, the genetic and causal relationships between anxiety-related disorders or specific anxiety disorders and reproductive phenotypes remain unknown. We utilized large-scale genome-wide association study (GWAS) results (n = 9537-542,901) for five reproductive phenotypes [age at menarche, age at first sexual intercourse (AFS), age at first birth (AFB), number of children ever born (NEB), and age at menopause] and five anxiety-related disorders [panic disorder, anxiety disorders from the ANGST and the UK biobank (UKBB), posttraumatic stress disorder (PTSD) and obsessive-compulsive disorder (OCD)]. To assess genetic correlations and causal associations, linkage disequilibrium score regression and Mendelian randomization analyses, respectively, were performed. We found that AFS and AFB were negatively correlated with anxiety disorders ANGST (AFS: r
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