Evidence map›Paper›PMID 35750709›Full record

ArticleScientific reports2022

Flat irregular pigment epithelial detachment over time and outcome of different treatment regimens.

Nazanin Ebrahimiadib, Mohammadreza Mehrabi Bahar, Hamid Riazi-Esfahani, Elias Khalili Pour, Fariba Ghassemi, Hooshang Faghihi, Ahmad Mirshahi, Ramak Roohipourmoallai, Alireza Lashay, Alireza Mahmoudi and 1 more

Abstract read
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In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nazanin EbrahimiadibEye Research Center, Farabi Eye Hospital, Retina Services, Tehran University of Medical Sciences, South Kargar Street, Qazvin SquareTehran, 1336616351, Iran.
Mohammadreza Mehrabi BaharEye Research Center, Farabi Eye Hospital, Retina Services, Tehran University of Medical Sciences, South Kargar Street, Qazvin SquareTehran, 1336616351, Iran.
Hamid Riazi-EsfahaniEye Research Center, Farabi Eye Hospital, Retina Services, Tehran University of Medical Sciences, South Kargar Street, Qazvin SquareTehran, 1336616351, Iran.
Elias Khalili PourEye Research Center, Farabi Eye Hospital, Retina Services, Tehran University of Medical Sciences, South Kargar Street, Qazvin SquareTehran, 1336616351, Iran.
Fariba GhassemiEye Research Center, Farabi Eye Hospital, Retina Services, Tehran University of Medical Sciences, South Kargar Street, Qazvin SquareTehran, 1336616351, Iran.
Hooshang FaghihiEye Research Center, Farabi Eye Hospital, Retina Services, Tehran University of Medical Sciences, South Kargar Street, Qazvin SquareTehran, 1336616351, Iran.
Ahmad MirshahiEye Research Center, Farabi Eye Hospital, Retina Services, Tehran University of Medical Sciences, South Kargar Street, Qazvin SquareTehran, 1336616351, Iran.
Ramak RoohipourmoallaiDepartment of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Alireza LashayEye Research Center, Farabi Eye Hospital, Retina Services, Tehran University of Medical Sciences, South Kargar Street, Qazvin SquareTehran, 1336616351, Iran.
Alireza MahmoudiEye Research Center, Farabi Eye Hospital, Retina Services, Tehran University of Medical Sciences, South Kargar Street, Qazvin SquareTehran, 1336616351, Iran.
Kaveh FadakarEye Research Center, Farabi Eye Hospital, Retina Services, Tehran University of Medical Sciences, South Kargar Street, Qazvin SquareTehran, 1336616351, Iran. Kaveh.fadakar@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To present long-term visual and structural outcome of treatment in two forms of flat irregular pigment epithelial detachment (FIPED): avascular (aFIPED) and vascularized (vFIPED) in eyes within pachychoroid spectrum. Prospective interventional case series. FIPED were classified into two subgroups; aFIPED and vFIPED based on OCTA. aFIPED underwent PDT, and vFIPED underwent either PDT, IVB, or combination of PDT&IVB. Vision, subretinal or intraretinal fluid, and choroidal biomarkers such as choroidal thickness, area, choroidal vascular index (CVI), and PED area were measured at baseline and last follow-up. Fifteen eyes with aFIPED were followed for a mean of 14.7 ± 10.8 months. Their vision improved, (0.44 ± 0.37-0.33 ± 0.40 LogMAR, p = 0.009) with significant reduction of fluid, choroidal area, thickness, PED area and increase in CVI. Twenty eyes with vFIPED were followed for a mean of 16.5 ± 8.2 months. The same pattern of choroidal alterations without visual improvement was observed in eyes underwent PDT alone. Combination therapy resulted in improvement of vision (0.38 ± 0.10-0.23 ± 0.17 LogMAR, p = 0.006) with reduction of choroidal area and thickness, with an increase in CVI. IVB alone could not change vision or choroidal structure. Single session PDT may lead to sustained visual improvement and structural change in eyes with aFIPED. Combination of PDT and IVB may be a better choice in eyes with vFIPED.

Indexed as

Choroidal NeovascularizationPhotochemotherapyRetinal DetachmentFluorescein AngiographyHumansProspective StudiesRetrospective StudiesTomography, Optical CoherenceTreatment OutcomeVisual Acuity

Identifiers

PMID35750709
PMCPMC9232631

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.