ArticleNature communications2022
A structural and functional subdivision in central orbitofrontal cortex.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Rethinking the centrality of brain areas in understanding functional organization.Nature neuroscience · 2026Review
- Distinct contributions of anterior and posterior orbitofrontal cortex to outcome-guided behavior.bioRxiv : the preprint server for biology · 2025Article
- Medial orbitofrontal cortex structure, function, and cognition associates with weight loss for laparoscopic sleeve gastrectomy.Obesity (Silver Spring, Md.) · 2025Article
- Semi-orthogonal subspaces for value mediate a binding and generalization trade-off.Nature neuroscience · 2024Article
- Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex.Nature communications · 2024Article
- Orbitofrontal high-gamma reflects spike-dissociable value and decision mechanisms.bioRxiv : the preprint server for biology · 2024Article
- Hierarchical action encoding in prefrontal cortex of freely moving macaques.Cell reports · 2023Article
- Widespread coding of navigational variables in prefrontal cortex.Current biology : CB · 2023Article
- Abstract Value Encoding in Neural Populations But Not Single Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Altered connectivity patterns of medial and lateral orbitofrontal cortex underlie the severity of bulimic symptoms.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Economic choice requires many cognitive subprocesses, including stimulus detection, valuation, motor output, and outcome monitoring; many of these subprocesses are associated with the central orbitofrontal cortex (cOFC). Prior work has largely assumed that the cOFC is a single region with a single function. Here, we challenge that unified view with convergent anatomical and physiological results from rhesus macaques. Anatomically, we show that the cOFC can be subdivided according to its much stronger (medial) or weaker (lateral) bidirectional anatomical connectivity with the posterior cingulate cortex (PCC). We call these subregions cOFCm and cOFCl, respectively. These two subregions have notable functional differences. Specifically, cOFCm shows enhanced functional connectivity with PCC, as indicated by both spike-field coherence and mutual information. The cOFCm-PCC circuit, but not the cOFCl-PCC circuit, shows signatures of relaying choice signals from a non-spatial comparison framework to a spatially framed organization and shows a putative bidirectional mutually excitatory pattern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.