ArticleArchives of disease in childhood. Fetal and neonatal edition2023
Lung ultrasound of the dependent lung detects real-time changes in lung volume in the preterm lamb.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Inter-rater agreement of a newborn calf lung ultrasound scoring system.Journal of veterinary internal medicine · 2026Article
- Computer-assisted analysis of pleural and subpleural lung ultrasound correlates with oxygenation in preterm infants.Scientific reports · 2026Article
- Lung function response to postnatal corticosteroids for the prevention and treatment of bronchopulmonary dysplasia.Pediatric research · 2025Observational
- Comparing Italian versus European strategies and technologies for respiratory care in NICU: results of a survey of the Union of European Neonatal and Perinatal Societies (UENPS) and the Italian Society of Neonatology (SIN).Italian journal of pediatrics · 2025Article
- Lung Ultrasound Assessment of Regional Distribution of Pulmonary Edema and Atelectasis in Infants with Evolving Bronchopulmonary Dysplasia.Diagnostics (Basel, Switzerland) · 2024Article
- Effect of different CPAP levels on ultrasound-assessed lung aeration and gas exchange in neonates.Respiratory research · 2024Observational
- Combining lung ultrasound and oscillatory mechanics for assessing lung disease in very preterm infants.Pediatric research · 2024Observational
- Lung ultrasound detects regional aeration inhomogeneity in ventilated preterm lambs.Pediatric research · 2024Article
- ERS International Congress 2022: highlights from the Paediatrics Assembly.ERJ open research · 2023Review
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEffective lung protective ventilation requires reliable, real-time estimation of lung volume at the bedside. Neonatal clinicians lack a readily available imaging tool for this purpose.
objectiveTo determine the ability of lung ultrasound (LUS) of the dependent region to detect real-time changes in lung volume, identify opening and closing pressures of the lung, and detect pulmonary hysteresis.
methodsLUS was performed on preterm lambs (n=20) during in vivo mapping of the pressure-volume relationship of the respiratory system using the super-syringe method. Electrical impedance tomography was used to derive regional lung volumes. Images were blindly graded using an expanded scoring system. The scores were compared with total and regional lung volumes, and differences in LUS scores between pressure increments were calculated.
resultsChanges in LUS scores correlated moderately with changes in total lung volume (r=0.56, 95% CI 0.47-0.64, p<0.0001) and fairly with right whole (r=0.41, CI 0.30-0.51, p<0.0001), ventral (r=0.39, CI 0.28-0.49, p<0.0001), central (r=0.41, CI 0.31-0.52, p<0.0001) and dorsal (r=0.38, CI 0.27-0.49, p<0.0001) regional lung volumes. The pressure-volume relationship of the lung exhibited hysteresis in all lambs. LUS was able to detect hysteresis in 17 (85%) lambs. The greatest changes in LUS scores occurred at the opening and closing pressures.
conclusionLUS was able to detect large changes in total and regional lung volume in real time and correctly identified opening and closing pressures but lacked the precision to detect small changes in lung volume. Further work is needed to improve precision prior to translation to clinical practice.
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