ArticleInternational review of neurobiology2022
Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder.
Article in International review of neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Similar DTI-ALPS metrics in Parkinson's disease and essential tremor: a cross-sectional comparative analysis.Neuroradiology · 2026Article
- Effects of subanesthetic dose of ketamine on motor and cognitive outcomes of harmaline-induced essential tremor model: a focus on Lingo-1 and inflammatory pathways.BMC neuroscience · 2025Article
- Pathophysiological Role of Primary Motor Cortex in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Brain Imaging Phenotypes Associated with Polygenic Risk for Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Neuropsychiatric Approaches to Essential and Functional Tremor: A Comparative Study.Neuropsychiatric disease and treatment · 2025Article
- Long-Term Outcomes of Patients with Pre-Existing Essential Tremor After SARS-CoV-2 Infection.Diagnostics (Basel, Switzerland) · 2024Article
- Decreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density.Cerebellum (London, England) · 2024Article
- Six Myths and Misconceptions about Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Review
- Decreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density.Research square · 2023Article
- Developing a Staging Scheme for Essential Tremor: A Discussion of Organizing Principles.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- Essential tremor: Is this an electrical or a degenerative disorder? Or is it both?International review of neurobiology · 2022Article
- The future of pharmacotherapies for essential tremor: Enhancing GABA neurotransmission or reducing neuronal hyperexcitability?International review of neurobiology · 2022Article
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1 author at 1 institution in 1 country.
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Abstract
Essential tremor (ET) is a highly prevalent neurologic disease and is the most common of the many tremor disorders. ET is a progressive condition with marked clinical heterogeneity, associated with a spectrum of both motor and non-motor features. However, its disease mechanisms remain poorly understood. Much debate has centered on whether ET should be considered a degenerative disorder, with underlying pathological changes in brain causing progressive disease manifestations, or an electric disorder, with overactivity of intrinsically oscillatory motor networks that occur without underlying structural brain abnormalities. Converging data from clinical, neuroimaging and pathological studies in ET now provide considerable evidence for the neurodegenerative hypothesis. A major turning point in this debate is that rigorous tissue-based studies have recently identified a series of structural changes in the ET cerebellum. Most of these pathological changes are centered on the Purkinje cell and connected neuronal populations, which can result in partial loss of Purkinje cells and circuitry reorganizations that would disturb cerebellar function. There is significant overlap in clinical and pathological features of ET with other disorders of cerebellar degeneration, and an increased risk of developing other degenerative diseases in ET. The combined implication of these studies is that ET could be degenerative. The evidence in support of the degenerative hypothesis is presented.
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