ArticlePharmacological research2022
Preferential Gs protein coupling of the galanin Gal
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Article in Pharmacological research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Emerging Insights into the Distinct Pharmacological Mechanisms of Buprenorphine.Journal of chemical information and modeling · 2026Article
- Galanin Receptors: G Protein-Dependent Signaling and Beyond.Biomolecules · 2026Review
- Early socially isolated rats of both sexes reduce alcohol consumption and seeking by the Galanin (1-15) and naltrexone combination.Frontiers in pharmacology · 2026Article
- Methadone and morphine have equivalent analgesic but not reward potency in female mice.Addiction neuroscience · 2025Article
- Single-molecule characterization of opioid receptor heterodimers reveals soluble µ-δ dimer blocker peptide alleviates morphine tolerance.Nature communications · 2025Article
- Single-molecule methods for characterizing receptor dimers reveal metastable opioid receptor homodimers that induce functional modulation.Nature communications · 2025Article
- Functional significance of opioid receptor homomers and heteromers.Nature communications · 2025Article
- Circuit-selective pharmacological targeting of prefrontal cortex-projecting locus coeruleus neurons drives antinociception.Cell reports · 2025Article
- Distinctive biochemical properties of the μ-opioid receptor-corticotropin- releasing factor CRFPharmacological research · 2025Article
- Locomotor activity depends on β-arrestin recruitment by the dopamine DPharmacological research · 2025Article
- Development of a HiBiT Peptide-Based NanoBRET Ligand Binding Assay for Galanin Receptor 1 in Live Cells.ACS chemical biology · 2025Article
- Design of Small Non-Peptidic Ligands That Alter Heteromerization between Cannabinoid CBJournal of medicinal chemistry · 2025Article
- Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone.Molecular psychiatry · 2024Article
- Modulation of Neuron and Astrocyte Dopamine Receptors via Receptor-Receptor Interactions.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Galanin receptor 3 - A new pharmacological target in retina degeneration.Pharmacological research · 2023Article
- Pharmacological targeting of G protein-coupled receptor heteromers.Pharmacological research · 2022Article
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 2 countries.
Paulo A De OliveiraIntegrative Neurobiology Section, USA.
Estefanía MorenoLaboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institute of Biomedicine, University of Barcelona, Barcelona, Spain.
Nil Casajuana-MartinLaboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Autonomous University of Barcelona, Bellaterra, Spain.
Verònica Casadó-AngueraLaboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institute of Biomedicine, University of Barcelona, Barcelona, Spain.
Ning-Sheng CaiIntegrative Neurobiology Section, USA.
Gisela Andrea Camacho-HernandezMedicinal Chemistry Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Hu ZhuDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Alessandro BonifaziMedicinal Chemistry Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Matthew D HallDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
David WeinshenkerDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Amy Hauck NewmanMedicinal Chemistry Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Diomedes E LogothetisDepartments of Pharmaceutical Sciences, Chemistry and Chemical Biology and Center for Drug Discovery, School of Pharmacy at the Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA, USA.
Vicent CasadóLaboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institute of Biomedicine, University of Barcelona, Barcelona, Spain. Electronic address: vcasado@ub.edu.
Leigh D PlantDepartments of Pharmaceutical Sciences, Chemistry and Chemical Biology and Center for Drug Discovery, School of Pharmacy at the Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA, USA. Electronic address: l.plant@northeastern.edu.
Leonardo PardoLaboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Autonomous University of Barcelona, Bellaterra, Spain. Electronic address: Leonardo.Pardo@uab.cat.
Sergi FerréIntegrative Neurobiology Section, USA. Electronic address: sferre@intra.nida.nih.gov.
Integrative Medicine Institute · USUniversitat de Barcelona · ESNational Center for Advancing Translational Sciences · USNational Institutes of Health · USNortheastern University · USUniversitat Autònoma de Barcelona · ESEmory University · USNational Institute on Drug Abuse · US
Funding
Neurotransmitter Receptor Heteromers in the Striatal Spine ModuleZIADA000493 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI FERRE, SERGI · 2009 to 2025
$35.6MContribution of locus coeruleus-derived galanin to opioid reward and reinforcementR01DA049257 · NIDA · EMORY UNIVERSITY · PI WEINSHENKER, DAVID · 2020 to 2024
$2.3MSUMO-regulation of ion channels via PIP2R01HL144615 · NHLBI · NORTHEASTERN UNIVERSITY · PI PLANT, LEIGH DANIEL · 2019 to 2022
$1.6MIntramural NIH HHS ZIA DA000493NHLBI NIH HHS R01 HL144615NIDA NIH HHS R01 DA049257
Abstract
Recent studies have proposed that heteromers of µ-opioid receptors (MORs) and galanin Gal
Indexed as
Analgesics, OpioidGalaninMesencephalonPeptidesReceptors, OpioidAnalgesics, OpioidGalaninPeptidesReceptors, OpioidDAMGO (PubChem CID: 5462471)Endomorphin-1 (PubChem CID: 5311080)Fentanyl (PubChem CID: 3345)Galanin (PubChem CID: 16133823)Galanin receptorsG protein coupled receptor oligomerizationM40 (PubChem CID: 16133821)M617 (PubChem CID: 16158157)Methadone (PubChem CID: 4095)Naloxone (PubChem CID: 5284596)Opioid receptorsTotal internal reflection fluorescence microscopy
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.