ArticleCell2022
Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes.
Open access · greenAbstract read
In one paragraph
Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers.
0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed
31.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
147 citing papers in PubMed, 230 citations in OpenAlex.
- Lysosomal dysfunction in neurodegenerative disease.Nature reviews. Neurology · 2026Review
- TLDc proteins: Stress-responsive nexus regulators of redox signaling, V-ATPase dynamics, and organellar crosstalk in neurodegeneration.Redox biology · 2026Review
- Lysosomes and lysosomal dysfunction in ageing biology.Nature cell biology · 2026Review
- Established and emerging roles of lysosomal dysfunction in cardiac aging.Nature cardiovascular research · 2026Review
- A nonhydrolyzable candesartan cilexetil analog reveals synergistic activation as a tractable mechanism for TMEM175 modulation.American journal of physiology. Cell physiology · 2026Article
- Compartmental pH regulation in cancer and antitumor immunity: therapeutic opportunities and challenges.Apoptosis : an international journal on programmed cell death · 2026Review
- Gaps in the Parkinson's disease therapeutic clinical pipeline: A focus on approaches targeting disease pathobiology.Journal of Parkinson's disease · 2026Review
- Switchable Enzyme-Regulated ECM-Integrin-Cholesterol Signaling Orchestrate PD-L1 Dual Destabilization for Boosting Photo-Immunotherapy.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- TMEM175 rescues post-infarct cardiac dysfunction via mTORC1-lysosomal axis modulation.Acta pharmacologica Sinica · 2026Article
- Dysregulation of the TFEB-ATP6V0C axis in microglia exacerbates α-synuclein pathology through impaired lysosomal acidification in Parkinson's disease.Cell death and differentiation · 2026Article
- Lysine acetyltransferase 8-mediated histone acetylation, regulated by GBA1, is associated with lysosomal function related to α-Synuclein pathology.Cell death & disease · 2026Article
- Isoginkgetin protects against degeneration of ALS motor neurons via regulating the GSK-3β-TFEB signaling axis.Pharmacological research · 2026Article
- NDST3 suppression restores lysosomal acidification and ameliorates amyloid-β and MAPT/tau pathology in Alzheimer's disease.Translational neurodegeneration · 2026Article
- Voltage-gated proton channel Hv1/VSOP regulates reciprocal interactions between F-actin and endosomes in microglia.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Regional gene expression and brain atrophy in dementia with Lewy bodies: an imaging transcriptomics study.NPJ Parkinson's disease · 2026Article
- Novel associations of VPS13C with phenotype and conversion of idiopathic REM sleep behavior disorder.NPJ Parkinson's disease · 2026Article
- Genetic dissection of rapid proteolysis identifies TXNDC15 as a key factor of ERAD and lipid homeostasis.bioRxiv : the preprint server for biology · 2026Article
- Lysosomal homeostasis at the crossroads of neurodegeneration.The Journal of clinical investigation · 2026Review
- Proton signaling links epithelial sensing to neural control of host defense in C. elegans.Nature communications · 2026Article
- CLN3 mediates chloride efflux from lysosomes.Neuron · 2026Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Meiqin HuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI 48109, USA; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address: meiqinhu@umich.edu.
Ping LiDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI 48109, USA; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Ce WangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI 48109, USA.
Xinghua FengCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China; Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China.
Qi GengDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI 48109, USA.
Wei ChenDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI 48109, USA.
Matangi MarthiDepartment of Microbiology & Immunology, University of Michigan Medical School, 6750 Med Sci II, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.
Wenlong ZhangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI 48109, USA; College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Harbin 150030, China.
Chenlang GaoDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI 48109, USA.
Whitney ReidDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI 48109, USA.
Joel SwansonDepartment of Microbiology & Immunology, University of Michigan Medical School, 6750 Med Sci II, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.
Wanlu DuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI 48109, USA.
Richard I HumeDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI 48109, USA.
Haoxing XuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI 48109, USA. Electronic address: haoxingx@umich.edu.
University of Michigan · USNortheast Agricultural University · CNSecond Affiliated Hospital of Zhejiang University · CN
Funding
The Regulation of MacropinocytosisR35GM131720 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWANSON, JOEL A · 2019 to 2023
$2.4MIon channels in the tubulovesiclesR01DK115474 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AKAABOUNE, MOHAMMED, DU, WANLU · 2018 to 2022
$1.4MNIDDK NIH HHS R01 DK115474NIGMS NIH HHS R35 GM131720
Abstract
Lysosomes require an acidic lumen between pH 4.5 and 5.0 for effective digestion of macromolecules. This pH optimum is maintained by proton influx produced by the V-ATPase and efflux through an unidentified "H
Indexed as
Parkinson DiseaseEndosomesHumansHydrogen-Ion ConcentrationIntracellular MembranesLysosomesPotassium ChannelsProtonsPotassium ChannelsProtonsTMEM175 protein, humanacidificationdegradationlysosomepH optimumProton channel
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.