Evidence map›Paper›PMID 35749573›Full record

ArticleBiomacromolecules2022

Metal-Free Radical Dendrimers as MRI Contrast Agents for Glioblastoma Diagnosis:

Songbai Zhang, Vega Lloveras, Silvia Lope-Piedrafita, Pilar Calero-Pérez, Shuang Wu, Ana Paula Candiota, José Vidal-Gancedo

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Biomacromolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 40 citations in OpenAlex.

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  12. Contrast Agents Based on Human Serum Albumin and Nitroxides forInternational journal of molecular sciences · 2024
    Article
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  15. Fluorinated Human Serum Albumin as PotentialMolecules (Basel, Switzerland) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Songbai ZhangInstitut de Ciència de Materials de Barcelona, ICMAB-CSIC; Campus UAB, 08193 Bellaterra, Spain.ORCID 0000-0003-1084-6483
Vega LloverasInstitut de Ciència de Materials de Barcelona, ICMAB-CSIC; Campus UAB, 08193 Bellaterra, Spain.ORCID 0000-0002-9653-3340
Silvia Lope-PiedrafitaCIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Campus UAB, 08913 Bellaterra, Spain.ORCID 0000-0002-8127-6425
Pilar Calero-PérezCIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Campus UAB, 08913 Bellaterra, Spain.
Shuang WuDepartament de Bioquímica i Biologia Molecular, Unitat de Bioquímica de Biociències, Edifici Cs, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Ana Paula CandiotaCIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Campus UAB, 08913 Bellaterra, Spain.ORCID 0000-0002-1523-6505
José Vidal-GancedoInstitut de Ciència de Materials de Barcelona, ICMAB-CSIC; Campus UAB, 08193 Bellaterra, Spain.
Universitat Autònoma de Barcelona · ESInstituto de Salud Carlos III · ESInstitut de Ciència de Materials de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Simultaneously being a nonradiative and noninvasive technique makes magnetic resonance imaging (MRI) one of the highly required imaging approaches for the early diagnosis and follow-up of tumors, specifically for brain cancer. Paramagnetic gadolinium (Gd)-based contrast agents (CAs) are the most widely used ones in brain MRI acquisitions with special interest when assessing blood-brain barrier (BBB) integrity, a characteristic of high-grade tumors. However, alternatives to Gd-based contrast agents (CAs) are highly required to overcome their established toxicity. Organic radicals anchored on a dendrimer macromolecule surface (radical dendrimers) are promising alternatives since they also exhibit paramagnetic properties and can act as

Indexed as

Brain NeoplasmsDendrimersGlioblastomaAnimalsContrast MediaFree RadicalsHumansMagnetic Resonance ImagingMetalsMiceContrast MediaDendrimersFree RadicalsMetals

Identifiers

PMID35749573
PMCPMC9277593
OpenAlexW4283464894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.